Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 5/20 | 0.58 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
| ▸ | CDC25B | P30305 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10916224 | 0.82 | ALOX15 (0.62) | ALOX15PTPN2PTPN1CDC25BMAPT | |
| SCHEMBL10406282 | 0.82 | ALOX15 (0.54) | ALOX15PTPN2PTPN1CDC25BALDH1A1 | |
| SCHEMBL10916221 | 0.82 | ALOX15 (0.62) | ALOX15PTPN2PTPN1CDC25BMAPT | |
| SCHEMBL3358127 | 0.82 | ALOX15 (0.54) | ALOX15PTPN2PTPN1CDC25BALDH1A1 | |
| SCHEMBL21032650 | 0.81 | ALOX15 (0.53) | ALOX15PTPN2PTPN1CDC25B | |
| SCHEMBL2059319 | 0.80 | ALOX15 (0.55) | ALOX15PTPN2PTPN1CDC25B | |
| SCHEMBL1188174 | 0.80 | ALOX15 (0.55) | ALOX15PTPN2PTPN1CDC25B | |
| SCHEMBL9718129 | 0.80 | ALOX15 (0.51) | ALOX15PTPN2PTPN1CDC25B | |
| SCHEMBL9718189 | 0.80 | ALOX15 (0.51) | ALOX15PTPN2PTPN1CDC25B | |
| SCHEMBL2058854 | 0.80 | ALOX15 (0.55) | ALOX15PTPN2PTPN1CDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11938101-B2 | Polymorphic forms of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide | PTC THERAPEUTICS, INC. (US) | 2024-03-26 | — | — | US | disclosed |
| US-9932286-B2 | Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers | BIOELECTRON TECHNOLOGY CORPORATION (US) | 2018-04-03 | — | — | US | disclosed |
| US-9932286-B2 | Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers | BIOELECTRON TECHNOLOGY CORPORATION (US) | 2018-04-03 | — | — | US | disclosed |
| EP-2617418-B1 | PHENOL AND 1,4-BENZOQUINONE DERIVATIVES FOR USE IN THE TREATMENT OF MITOCHONDRIAL DISEASES | BIOELECTRON TECH CORP (US) | 2017-11-22 | — | — | EP | disclosed |
| US-20160244392-A1 | SIDE-CHAIN VARIANTS OF REDOX-ACTIVE THERAPEUTICS FOR TREATMENT OF MITOCHONDRIAL DISEASES AND OTHER CONDITIONS AND MODULATION OF ENERGY BIOMARKERS | PTC THERAPEUTICS, INC. | 2016-08-25 | — | — | US | disclosed |
| US-20160244392-A1 | SIDE-CHAIN VARIANTS OF REDOX-ACTIVE THERAPEUTICS FOR TREATMENT OF MITOCHONDRIAL DISEASES AND OTHER CONDITIONS AND MODULATION OF ENERGY BIOMARKERS | PTC THERAPEUTICS, INC. | 2016-08-25 | — | — | US | disclosed |
| US-9278085-B2 | Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers | EDISON PHARMACEUTICALS, INC. (US) | 2016-03-08 | — | — | US | disclosed |
| US-9278085-B2 | Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers | EDISON PHARMACEUTICALS, INC. (US) | 2016-03-08 | — | — | US | disclosed |
| EP-2617418-A1 | Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers | Edison Pharmaceuticals, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| EP-2617417-A1 | Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers | Edison Pharmaceuticals, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| EP-2332534-A1 | Phenol and benzoquinone derivatives for use in the treatment of mitochondrial diseases and modulation of energy biomarkers | Edison Pharmaceuticals, Inc. (US) | 2011-06-15 | — | — | EP | disclosed |
| US-20100297262-A1 | PHARMACEUTICALLY ACTIVE COMPOSITIONS COMPRISING OXIDATIVE STRESS MODULATORS (OSM), NEW CHEMICAL ENTITIES, COMPOSITIONS AND USES | COLBY PHARMACEUTICAL COMPANY (US) | 2010-11-25 | — | — | US | disclosed |
| US-20070225261-A1 | Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers | PTC THERAPEUTICS, INC. | 2007-09-27 | — | — | US | disclosed |
| US-20070225261-A1 | Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers | PTC THERAPEUTICS, INC. | 2007-09-27 | — | — | US | disclosed |
| WO-2007100652-A2 | SIDE CHAIN VARIANTS OF REDOX-ACTIVE THERAPEUTICS FOR TREATMENT OF MITOCHONDRIAL DISEASES AND OTHER CONDITIONS AND MODULATION OF ENERGY BIOMARKERS | EDISON PHARMACEUTICALS, INC. (US) | 2007-09-07 | — | — | WO | disclosed |
| EP-0846109-B1 | QUINONE COMPOUND, ITS PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-07-24 | — | — | EP | disclosed |
| US-6011046-A | Quinone compound, its production and use as antioxidant | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-01-04 | — | — | US | disclosed |
| EP-0846109-A1 | QUINONE COMPOUND, ITS PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1998-06-10 | — | — | EP | disclosed |
| WO-1997007109-A1 | QUINONE COMPOUND, ITS PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160244392-A1 | SIDE-CHAIN VARIANTS OF REDOX-ACTIVE THERAPEUTICS FOR TREATMENT OF MITOCHONDRIAL DISEASES AND OTHER CONDITIONS AND MODULATION OF ENERGY BIOMARKERS | FH, NDUFAB1, ACAA2 | ALOX15 420/4885PTPN2 4781/4885PTPN1 4730/4885 |
| US-11938101-B2 | Polymorphic forms of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide | HADHA, ACAA2, HOGA1 | ALOX15 2705/4885PTPN2 4159/4885PTPN1 4287/4885 |
| US-20100297262-A1 | PHARMACEUTICALLY ACTIVE COMPOSITIONS COMPRISING OXIDATIVE STRESS MODULATORS (OSM), NEW CHEMICAL ENTITIES, COMPOSITIONS AND USES | MPO, HMOX1, LPO | ALOX15 64/4885PTPN2 1912/4885PTPN1 1958/4885 |
| US-20070225261-A1 | Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers | FH, NDUFAB1, ACAA2 | ALOX15 420/4885PTPN2 4781/4885PTPN1 4730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.