Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 8/20 | 0.55 |
| ▸ | CHRND | Q07001 | 6/20 | 0.53 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.53 |
| ▸ | CHRNG | P07510 | 2/20 | 0.53 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703636 | 0.88 | MME (0.50) | GRIA1 | |
| SCHEMBL7709387 | 0.85 | CTSL (0.55) | GRIA1CHRNDGAAMAPTSMN1; SMN2 | |
| SCHEMBL7515768 | 0.84 | PTGS2 (0.51) | GRIA1CHRNDGAAMAPT | |
| SCHEMBL7520851 | 0.84 | PTGS2 (0.51) | GRIA1CHRNDGAAMAPT | |
| SCHEMBL5370187 | 0.83 | NAALAD2 (0.54) | GRIA1GAAMAPTSMN1; SMN2 | |
| SCHEMBL7709347 | 0.83 | NAALAD2 (0.54) | GRIA1GAAMAPTSMN1; SMN2 | |
| SCHEMBL7709781 | 0.82 | MEN1 (0.56) | GRIA1CHRNDCHRNA1CHRNGCHRNB1 | |
| SCHEMBL7605515 | 0.82 | MAPT (0.54) | GRIA1CHRNDCHRNA1CHRNGCHRNB1 | |
| SCHEMBL7517509 | 0.81 | CTSL (0.59) | GRIA1CHRNDCHRNA1CHRNGCHRNB1 | |
| SCHEMBL7689080 | 0.80 | CTSS (0.65) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362165-B1 | Hydroxyphenyl derivatives with HIV integrase inhibitory properties | PHARMACOR INC. (CA) | 2002-03-26 | — | — | US | disclosed |
| EP-1165492-A1 | HYDROXYPHENYL DERIVATIVES WITH HIV INTEGRASE INHIBITORY PROPERTIES | Pharmacor Inc. (CA) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059867-A1 | HYDROXYPHENYL DERIVATIVES WITH HIV INTEGRASE INHIBITORY PROPERTIES | PHARMACOR INC. (CA) | 2000-10-12 | — | — | WO | disclosed |