SCHEMBL756254

SCHEMBL756254

CCOC(Cc1cccc(N)c1)C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PPARG P37231 17/20 0.57
PPARA Q07869 17/20 0.57
PPARD Q03181 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1706161 0.95 PPARA (0.54) PPARGPPARAPPARD
SCHEMBL4081032 0.87 PPARG (0.44) PPARGPPARAPPARD
SCHEMBL1861279 0.86 PPARG (0.44) PPARGPPARAPPARD
SCHEMBL1104874 0.85 PPARG (0.43) PPARGPPARAPPARD
SCHEMBL757308 0.85 SRR (0.53) PPARGPPARAPPARD
SCHEMBL15679980 0.85 SRR (0.53) PPARGPPARAPPARD
SCHEMBL1094834 0.85 SRR (0.53) PPARGPPARAPPARD
SCHEMBL1094835 0.85 SRR (0.53) PPARGPPARAPPARD
SCHEMBL14477219 0.85 PPARG (0.45) PPARGPPARAPPARD
SCHEMBL1670312 0.82 PPARA (0.69) PPARGPPARAPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 137 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180064667-A1 METHODS OF TREATING LACTOSE INTOLERANCE NOGRA PHARMA LTD (IE) 2018-03-08 US claimed
US-9682050-B2 Methods of treating lactose intolerance NOGRA PHARMA LIMITED (IE) 2017-06-20 US claimed
US-20150087678-A1 METHODS OF TREATING LACTOSE INTOLERANCE NOGRA PHARMA LIMITED (IE) 2015-03-26 US claimed
EP-2844242-A1 METHODS OF TREATING LACTOSE INTOLERANCE Nogra Pharma Limited (IE) 2015-03-11 EP claimed
WO-2013156413-A1 METHODS OF TREATING LACTOSE INTOLERANCE NOGRA PHARMA LIMITED (IE) 2013-10-24 WO claimed
EP-1910270-B1 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD NOGRA PHARMA LTD (IE) 2013-05-08 EP claimed
EP-2131829-B1 PPAR-gamma agonists for the induction of cationic antimicrobial peptide expression as immunoprotective stimulants GIULIANI INT LTD (IE) 2012-04-18 EP claimed
US-8153693-B2 Compounds for the selective treatment of the intestinal immuno-inflammatory component of the celiac disease GIULIANI INTERNATIONAL LIMITED (IE) 2012-04-10 US claimed
EP-2222291-B1 COMPOUNDS FOR THE SELECTIVE TREATMENT OF THE INTESTINAL IMMUNO-INFLAMMATORY COMPONENT OF THE CELIAC DISEASE GIULIANI INT LTD (IE) 2012-03-21 EP claimed
US-20110152225-A1 PPAR-Gamma Agonists for the Induction of Cationic Antimicrobial Peptide Expression as Immunoprotective Stimulants NOGRA PHARMA LIMITED (IE) 2011-06-23 US claimed
EP-2222291-A2 COMPOUNDS FOR THE SELECTIVE TREATMENT OF THE INTESTINAL IMMUNO-INFLAMMATORY COMPONENT OF THE CELIAC DISEASE Giuliani International Limited (IE) 2010-09-01 EP claimed
EP-2131829-A1 PPAR-GAMMA AGONISTS FOR THE INDUCTION OF CATIONIC ANTIMICROBIAL PEPTIDE EXPRESSION AS IMMUNOPROTECTIVE STIMULANTS Giuliani International Limited (IE) 2009-12-16 EP claimed
WO-2009080828-A2 COMPOUNDS FOR THE SELECTIVE TREATMENT OF THE INTESTINAL IMMUNO-INFLAMMATORY COMPONENT OF THE CELIAC DISEASE GIULIANI INTERNATIONAL LIMITED (IE) 2009-07-02 WO claimed
US-20090048343-A1 Compounds and Their Salts Specific to the PPAR Receptors and the EGF Receptors and Their Use in the Medical Field NOGRA PHARMA LIMITED (IE) 2009-02-19 US claimed
WO-2008104557-A1 PPAR-GAMMA AGONISTS FOR THE INDUCTION OF CATIONIC ANTIMICROBIAL PEPTIDE EXPRESSION AS IMMUNOPROTECTIVE STIMULANTS GIULIANI INTERNATIONAL LIMITED (IE) 2008-09-04 WO claimed
EP-1910270-A2 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD Giuliani International Limited (IE) 2008-04-16 EP claimed
WO-2007010516-A2 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD GIULIANI INTERNATIONAL LIMITED (IE) 2007-01-25 WO claimed
US-11753365-B2 Methods of treating fibrosis NOGRA PHARMA LIMITED (IE) 2023-09-12 US disclosed
WO-2007010516-A2 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD GIULIANI INTERNATIONAL LIMITED (IE) 2007-01-25 WO disclosed
WO-2007010516-A2 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD GIULIANI INTERNATIONAL LIMITED (IE) 2007-01-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11753365-B2 Methods of treating fibrosis MMP1, MMP8, FABP2 PPARG 669/4885PPARA 648/4885PPARD 1293/4885
US-20150087678-A1 METHODS OF TREATING LACTOSE INTOLERANCE LCT, LPL, PPARG PPARG 3/4885PPARA 4/4885PPARD 6/4885
US-20090048343-A1 Compounds and Their Salts Specific to the PPAR Receptors and the EGF Receptors and Their Use in the Medical Field EGFR, ERBB3, FGFR3 PPARG 4/4885PPARA 9/4885PPARD 12/4885
US-20180064667-A1 METHODS OF TREATING LACTOSE INTOLERANCE LCT, LPL, PPARG PPARG 3/4885PPARA 4/4885PPARD 6/4885
US-20110152225-A1 PPAR-Gamma Agonists for the Induction of Cationic Antimicrobial Peptide Expression as Immunoprotective Stimulants PPARG, FABP2, PPARD PPARG 1/4885PPARA 4/4885PPARD 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.