Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.39 |
| ▸ | CA2 | P00918 | 4/20 | 0.39 |
| ▸ | CA9 | Q16790 | 4/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471533 | 0.87 | MAPT (0.45) | LMNATP53CMA1KMT2APOLB | |
| SCHEMBL7465217 | 0.84 | S1PR2 (0.39) | LMNAS1PR2TP53POLBMAPT | |
| SCHEMBL7472833 | 0.83 | MAPT (0.48) | LMNATP53CMA1KMT2APOLB | |
| SCHEMBL7563746 | 0.82 | MAPT (0.49) | LMNAS1PR2TP53KDM4EKMT2A | |
| SCHEMBL7465177 | 0.82 | S1PR2 (0.49) | LMNAS1PR2TP53CMA1KDM4E | |
| SCHEMBL7468006 | 0.82 | MAPT (0.46) | LMNAS1PR2TP53CMA1KMT2A | |
| SCHEMBL7465874 | 0.80 | AKR1B1 (0.50) | CMA1HDAC6PPARGPPARDPPARA | |
| SCHEMBL7460699 | 0.79 | NLRP3 (0.45) | LMNATP53KDM4EKMT2APOLB | |
| SCHEMBL7468517 | 0.79 | HDAC6 (0.52) | CMA1KMT2AMAPTHDAC6HDAC1 | |
| SCHEMBL7468103 | 0.79 | GAA (0.44) | LMNATP53CMA1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |