Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 3/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL760901 | 0.86 | FFAR1 (0.47) | FFAR1FFAR4PTGDR2S100A4KMT2A | |
| SCHEMBL5162483 | 0.83 | FFAR1 (0.44) | FFAR1FFAR4PTGS2PTGS1 | |
| SCHEMBL758542 | 0.82 | DPP4 (0.47) | FFAR1FFAR4KMT2APTGS2 | |
| SCHEMBL3746249 | 0.78 | FFAR1 (0.50) | FFAR1FFAR4PTGDR2KMT2AMEN1 | |
| SCHEMBL759109 | 0.77 | FFAR1 (0.46) | FFAR1FFAR4PTGDR2S100A4KMT2A | |
| SCHEMBL31464099 | 0.77 | FFAR1 (0.46) | FFAR1FFAR4PTGDR2S100A4KMT2A | |
| SCHEMBL4706171 | 0.76 | IDO1 (0.48) | KMT2AMEN1HPGDCYP3A4NPC1 | |
| SCHEMBL27417857 | 0.76 | FFAR1 (0.48) | FFAR1FFAR4PTGDR2S100A4KMT2A | |
| SCHEMBL17545797 | 0.76 | FFAR1 (0.48) | FFAR1FFAR4PTGDR2S100A4KMT2A | |
| SCHEMBL3746360 | 0.76 | FFAR4 (0.66) | FFAR1FFAR4PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841772-B1 | TETRAHYDROFURANE DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | SANOFI SA (FR) | 2015-05-06 | — | — | EP | disclosed |
| EP-1670766-B1 | Bicyclic imino acid derivatives for the treatment of (inter alia) diseases relating to the locomotor system | SANOFI AVENTIS DEUTSCHLAND (DE) | 2012-03-21 | — | — | EP | disclosed |
| US-8039481-B2 | Tetrahydrofuran derivatives for use as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS (FR) | 2011-10-18 | — | — | US | disclosed |
| US-7399770-B2 | Thieno-imino acid derivatives for use as matrix metalloproteinase inhibitors | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-07-15 | — | — | US | disclosed |
| US-20080039489-A1 | TETRAHYDROFURAN DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-02-14 | — | — | US | disclosed |
| EP-1841772-A1 | TETRAHYDROFURANE DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | Sanofi-Aventis (FR) | 2007-10-10 | — | — | EP | disclosed |
| US-20070203118-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRUGS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-08-30 | — | — | US | disclosed |
| US-20070093482-A1 | THIENO-IMINO ACID DERIVATIVES FOR USE AS MATRIX METALLOPROTEINASE INHIBITORS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-04-26 | — | — | US | disclosed |
| US-7205315-B2 | Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-04-17 | — | — | US | disclosed |
| EP-1763516-A2 | SUBSTITUTED TETRAHYDROISOCHINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRAGS | Sanofi-Aventis Deutschland GmbH (DE) | 2007-03-21 | — | — | EP | disclosed |
| EP-1723148-A2 | THIENO-IMINO ACID DERIVATIVES FOR USE AS MATRIX METALLOPROTEINASE INHIBITORS | Sanofi-Aventis Deutschland GmbH (DE) | 2006-11-22 | — | — | EP | disclosed |
| WO-2006077013-A1 | TETRAHYDROFURANE DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | SANOFI-AVENTIS (DE) | 2006-07-27 | — | — | WO | disclosed |
| EP-1670766-A1 | BICYCLIC IMINO ACID DERIVATIVES USED AS INHIBITORS OF MATRIX-METALLOPROTEINASES | Sanofi-Aventis Deutschland GmbH (DE) | 2006-06-21 | — | — | EP | disclosed |
| WO-2006002763-A2 | SUBSTITUTED TETRAHYDROISOCHINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRAGS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-01-12 | — | — | WO | disclosed |
| WO-2005073236-A2 | THIENO-IMINO ACID DERIVATIVES FOR USE AS MATRIX METALLOPROTEINASE INHIBITORS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2005-08-11 | — | — | WO | disclosed |
| US-20050080127-A1 | Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-04-14 | — | — | US | disclosed |
| WO-2005030728-A1 | BICYCLIC IMINO ACID DERIVATIVES USED AS INHIBITORS OF MATRIX-METALLOPROTEINASES | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080127-A1 | Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases | MMP1, MMP17, MMP25 | FFAR1 2951/4885FFAR4 4232/4885PTGDR2 499/4885 |
| US-20070093482-A1 | THIENO-IMINO ACID DERIVATIVES FOR USE AS MATRIX METALLOPROTEINASE INHIBITORS | MMP1, MIF, MMP12 | FFAR1 2741/4885FFAR4 3898/4885PTGDR2 330/4885 |
| US-20080039489-A1 | TETRAHYDROFURAN DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | MMP1, MMP17, MMP2 | FFAR1 3581/4885FFAR4 4317/4885PTGDR2 244/4885 |
| US-20070203118-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRUGS | MMP9, MMP2, MMP3 | FFAR1 3332/4885FFAR4 3662/4885PTGDR2 594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.