Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 5/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7152434 | 0.85 | DPP4 (0.50) | DPP4KMT2APTGER1PTGER4PTGER3 | |
| SCHEMBL756963 | 0.82 | FFAR1 (0.45) | KMT2APTGS2FFAR1FFAR4 | |
| SCHEMBL11094357 | 0.81 | DPP4 (0.50) | DPP4KMT2APTGER1PTGER4PTGER3 | |
| SCHEMBL5162483 | 0.80 | FFAR1 (0.44) | PTGS2FFAR1FFAR4 | |
| SCHEMBL30634145 | 0.79 | TAAR1 (0.52) | — | |
| SCHEMBL786089 | 0.79 | TAAR1 (0.52) | — | |
| SCHEMBL11333152 | 0.77 | DPP4 (0.65) | DPP4KMT2APTGER1PTGER4PTGER3 | |
| SCHEMBL5162634 | 0.75 | LMNA (0.38) | KMT2AFOLH1PTGS2 | |
| SCHEMBL1567126 | 0.74 | DPP4 (0.56) | DPP4KMT2APTGER1PTGER4PTGER3 | |
| SCHEMBL11057696 | 0.74 | DPP4 (0.56) | DPP4KMT2APTGER1PTGER4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841772-B1 | TETRAHYDROFURANE DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | SANOFI SA (FR) | 2015-05-06 | — | — | EP | disclosed |
| EP-1670766-B1 | Bicyclic imino acid derivatives for the treatment of (inter alia) diseases relating to the locomotor system | SANOFI AVENTIS DEUTSCHLAND (DE) | 2012-03-21 | — | — | EP | disclosed |
| US-8039481-B2 | Tetrahydrofuran derivatives for use as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS (FR) | 2011-10-18 | — | — | US | disclosed |
| US-7399770-B2 | Thieno-imino acid derivatives for use as matrix metalloproteinase inhibitors | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-07-15 | — | — | US | disclosed |
| US-20080039489-A1 | TETRAHYDROFURAN DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-02-14 | — | — | US | disclosed |
| EP-1841772-A1 | TETRAHYDROFURANE DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | Sanofi-Aventis (FR) | 2007-10-10 | — | — | EP | disclosed |
| US-20070203118-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRUGS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-08-30 | — | — | US | disclosed |
| US-20070093482-A1 | THIENO-IMINO ACID DERIVATIVES FOR USE AS MATRIX METALLOPROTEINASE INHIBITORS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-04-26 | — | — | US | disclosed |
| US-7205315-B2 | Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-04-17 | — | — | US | disclosed |
| EP-1763516-A2 | SUBSTITUTED TETRAHYDROISOCHINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRAGS | Sanofi-Aventis Deutschland GmbH (DE) | 2007-03-21 | — | — | EP | disclosed |
| EP-1723148-A2 | THIENO-IMINO ACID DERIVATIVES FOR USE AS MATRIX METALLOPROTEINASE INHIBITORS | Sanofi-Aventis Deutschland GmbH (DE) | 2006-11-22 | — | — | EP | disclosed |
| WO-2006077013-A1 | TETRAHYDROFURANE DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | SANOFI-AVENTIS (DE) | 2006-07-27 | — | — | WO | disclosed |
| EP-1670766-A1 | BICYCLIC IMINO ACID DERIVATIVES USED AS INHIBITORS OF MATRIX-METALLOPROTEINASES | Sanofi-Aventis Deutschland GmbH (DE) | 2006-06-21 | — | — | EP | disclosed |
| WO-2006002763-A2 | SUBSTITUTED TETRAHYDROISOCHINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRAGS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-01-12 | — | — | WO | disclosed |
| WO-2005073236-A2 | THIENO-IMINO ACID DERIVATIVES FOR USE AS MATRIX METALLOPROTEINASE INHIBITORS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2005-08-11 | — | — | WO | disclosed |
| US-20050080127-A1 | Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-04-14 | — | — | US | disclosed |
| WO-2005030728-A1 | BICYCLIC IMINO ACID DERIVATIVES USED AS INHIBITORS OF MATRIX-METALLOPROTEINASES | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080127-A1 | Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases | MMP1, MMP17, MMP25 | DPP4 953/4885KMT2A 3168/4885PTGER1 173/4885 |
| US-20070093482-A1 | THIENO-IMINO ACID DERIVATIVES FOR USE AS MATRIX METALLOPROTEINASE INHIBITORS | MMP1, MIF, MMP12 | DPP4 1963/4885KMT2A 3611/4885PTGER1 44/4885 |
| US-20080039489-A1 | TETRAHYDROFURAN DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | MMP1, MMP17, MMP2 | DPP4 570/4885KMT2A 3884/4885PTGER1 128/4885 |
| US-20070203118-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRUGS | MMP9, MMP2, MMP3 | DPP4 334/4885KMT2A 687/4885PTGER1 234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.