Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 6/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7659833 | 0.78 | TACR1 (0.45) | MTNR1AMTNR1BEGFRTACR1SRC | |
| SCHEMBL7657110 | 0.76 | HTR6 (0.48) | MTNR1AMTNR1BEGFRTACR1SRC | |
| SCHEMBL7790369 | 0.76 | CXCR2 (0.52) | MTNR1AMTNR1BEGFRTACR1SRC | |
| SCHEMBL7655822 | 0.75 | TACR1 (0.56) | TACR1CYP11B1CYP11B2KDM4EALDH1A1 | |
| SCHEMBL7575218 | 0.75 | MTNR1A (0.47) | MTNR1AEGFRCCNB2CDK1CCNB1 | |
| SCHEMBL7798973 | 0.74 | TACR1 (0.48) | MTNR1AMTNR1BEGFRTACR1SRC | |
| SCHEMBL7238513 | 0.74 | TSPO (0.56) | TACR1TSPOKDM4EALDH1A1HPGD | |
| SCHEMBL7233182 | 0.72 | TACR1 (0.50) | MTNR1AMTNR1BEGFRTACR1SRC | |
| SCHEMBL6805872 | 0.71 | TSPO (0.47) | MTNR1AMTNR1BTACR1TSPOKDM4E | |
| SCHEMBL7253117 | 0.71 | GSK3A (0.69) | CCNB2CDK1CCNB1GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476045-B2 | INDOLE AND AZAINDOLE DERIVATIVES AND THEIR USE AS TACHYKININ ANTAGONISTS, AND IN PARTICULAR AS NEUROKININ-1 RECEPTOR ANTAGONIST | MERCK SHARP & DOHME LTD. (GB) | 2002-11-05 | — | — | US | disclosed |
| US-20020022624-A1 | Azaindole derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 2002-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020022624-A1 | Azaindole derivatives and their use as therapeutic agents | HTR2B, HNMT, HTR1B | MTNR1A 356/4885MTNR1B 145/4885EGFR 2339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.