Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PRNP | P04156 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21508445 | 0.84 | KDM4E (0.43) | KDM4EKMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL4543263 | 0.83 | CYP1A2 (0.56) | AURKAPOLBKDM4EMEN1PRNP | |
| SCHEMBL20447560 | 0.83 | KDM4E (0.44) | AURKAPOLBKDM4EMEN1GAA | |
| SCHEMBL15305786 | 0.79 | KDM4E (0.46) | POLBKDM4EMEN1PRNPGAA | |
| SCHEMBL14298343 | 0.79 | L3MBTL1 (0.54) | POLBKDM4EMEN1PRNPGAA | |
| SCHEMBL5629171 | 0.79 | KDM4E (0.46) | POLBKDM4EMEN1PRNPGAA | |
| SCHEMBL17518970 | 0.78 | ATR (0.53) | ALDH1A1 | |
| SCHEMBL27654591 | 0.78 | RAB9A (0.48) | POLBKDM4EMEN1PRNPGAA | |
| SCHEMBL1786698 | 0.77 | KMT2A (0.47) | AURKAPOLBKDM4EMEN1PRNP | |
| SCHEMBL22186826 | 0.76 | KDM4E (0.69) | POLBKDM4EMEN1PRNPGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240417405-A1 | Substituted Spiro Derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2024-12-19 | — | — | US | disclosed |
| CN-117730081-A | Substituted spirocyclic derivatives | 詹森药业有限公司 | 2024-03-19 | — | — | CN | disclosed |
| EP-4334320-A1 | SUBSTITUTED SPIRO DERIVATIVES | JANSSEN Pharmaceutica NV (BE) | 2024-03-13 | — | — | EP | disclosed |
| WO-2022237627-A1 | SUBSTITUTED SPIRO DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2022-11-17 | — | — | WO | disclosed |
| CN-108947970-B | Indazole derivative and preparation method and application thereof | 四川大学 | 2022-04-05 | — | — | CN | disclosed |
| US-20120053345-A1 | Indazole Compounds | ABBOTT LABORATORIES (US) | 2012-03-01 | — | — | US | disclosed |
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| EP-1307454-B1 | DERIVATIVES OF VARIOLIN B | PHARMA MAR SA (ES) | 2009-06-03 | — | — | EP | disclosed |
| CN-100424083-C | Pyrimidine derivative compound and its preparing method | GUANGXI NAT UNIV (CN) | 2008-10-08 | — | — | CN | disclosed |
| US-7329666-B2 | Derivatives of variolin B | PHARMA MAR, S.A. (ES) | 2008-02-12 | — | — | US | disclosed |
| US-20080033001-A1 | Derivatives of Variolin B | UNIVERSIDAD DE BARCELONA (ES) | 2008-02-07 | — | — | US | disclosed |
| US-20080033001-A1 | Derivatives of Variolin B | UNIVERSIDAD DE BARCELONA (ES) | 2008-02-07 | — | — | US | disclosed |
| US-20080033001-A1 | Derivatives of Variolin B | UNIVERSIDAD DE BARCELONA (ES) | 2008-02-07 | — | — | US | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
| CN-1935805-A | Pyrimidine derivative compound and its preparing method | GUANGXI NAT UNIV (CN) | 2007-03-28 | — | — | CN | disclosed |
| CN-1275965-C | Derivatives of variolin b | UNIV BARCELONA (ES) | 2006-09-20 | — | — | CN | disclosed |
| US-20040058939-A1 | Derivatives of variolin b | PHARMA MAR, S.A. (ES) | 2004-03-25 | — | — | US | disclosed |
| CN-1468240-A | Derivatives of variolin b | �ϼ��������Ǵ�ѧ | 2004-01-14 | — | — | CN | disclosed |
| EP-1307454-A1 | DERIVATIVES OF VARIOLIN B | Universidad de Barcelona (ES) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002012240-A1 | DERIVATIVES OF VARIOLIN B | UNIVERSIDAD DE BARCELONA (ES) | 2002-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080033001-A1 | Derivatives of Variolin B | ARG2, SDHB, OAT | AURKA 638/4885POLB 1449/4885KDM4E 1443/4885 |
| US-20070282101-A1 | Indazole compounds | CYP3A43, CYP3A7, UGT1A1 | AURKA 479/4885POLB 3140/4885KDM4E 3676/4885 |
| US-20040058939-A1 | Derivatives of variolin b | HNRNPA2B1, HNRNPAB, SYNCRIP | AURKA 1034/4885POLB 1365/4885KDM4E 1485/4885 |
| US-20240417405-A1 | Substituted Spiro Derivatives | BMI1, MLLT1, MLLT3 | AURKA 3212/4885POLB 4059/4885KDM4E 671/4885 |
| US-20120053345-A1 | Indazole Compounds | CYP3A43, CYP3A7, UGT1A1 | AURKA 479/4885POLB 3140/4885KDM4E 3676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.