SCHEMBL7590145

SCHEMBL7590145

CCC(C)OC(=O)c1cc(C(F)(F)F)c(F)c(F)c1F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.39
CTSS P25774 2/20 0.35
GABRA1 P14867 3/20 0.33
GABRG2 P18507 3/20 0.33
GABRB3 P28472 3/20 0.33
GABRA5 P31644 3/20 0.33
GABRA3 P34903 3/20 0.33
GABRA2 P47869 3/20 0.33
ADRA1A P35348 1/20 0.33
TP53 P04637 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
GABRA6 Q16445 1/20 0.33
ALDH1A1 P00352 2/20 0.33
CFTR P13569 1/20 0.32
CES2 O00748 1/20 0.32
SCN1A P35498 1/20 0.32
SCN2A Q99250 1/20 0.32
SCN3A Q9NY46 1/20 0.32
NOTUM Q6P988 1/20 0.31
PKM P14618 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7595315 0.90 ALDH1A1 (0.39) L3MBTL1CTSSALDH1A1CFTR
SCHEMBL7597693 0.86 CA12 (0.41) ALDH1A1CFTRCES2PKM
SCHEMBL7596453 0.81 L3MBTL1 (0.40) L3MBTL1GABRA1GABRG2GABRB3GABRA5
SCHEMBL7593446 0.80 TSHR (0.44) L3MBTL1TP53ALDH1A1
SCHEMBL7595676 0.79 ALDH1A1 (0.49) CTSSTP53ALDH1A1SMN1; SMN2
SCHEMBL7595297 0.78 CFTR (0.50) CFTRCES2NOTUM
SCHEMBL7591337 0.78 ALDH1A1 (0.47) L3MBTL1TP53ALDH1A1
SCHEMBL7592823 0.77 ALDH1A1 (0.42) L3MBTL1CTSSGABRA1GABRA3ALDH1A1
SCHEMBL7595049 0.77 CTSS (0.33) L3MBTL1CTSSALDH1A1CFTRCES2
SCHEMBL7590153 0.75 TSHR (0.50) L3MBTL1TP53ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0968994-B1 PROCESS FOR PRODUCING SUBSTITUTED TRIFLUOROBENZOIC ACIDS AND ESTERS THEREOF UBE INDUSTRIES (JP) 2002-11-06 EP claimed
EP-0968994-A1 SUBSTITUTED TRIFLUOROBENZOIC ACIDS, ESTERS THEREOF, AND PROCESS FOR PRODUCING THE SAME UBE INDUSTRIES, LTD. (JP) 2000-01-05 EP claimed
EP-0968994-B1 PROCESS FOR PRODUCING SUBSTITUTED TRIFLUOROBENZOIC ACIDS AND ESTERS THEREOF UBE INDUSTRIES (JP) 2002-11-06 EP disclosed
US-6307091-B1 TRIFLUOROMETHYLATING A TRIFLUOROIODOBENZOIC ACID ESTER WITH ADIFLUORO(FLUOROSULFONYL)ACETIC ACID ESTER IN THE PRESENCE OF A COPPER CATALYST IN AN ORGANIC SOLVENT. UBE INDUSTRIES, LTD. (JP) 2001-10-23 US disclosed
US-6160171-A Trifluoro-substituted benzoic acid, esters thereof, and process for producing the same UBE INDUSTRIES, LTD. (JP) 2000-12-12 US disclosed
EP-0968994-A1 SUBSTITUTED TRIFLUOROBENZOIC ACIDS, ESTERS THEREOF, AND PROCESS FOR PRODUCING THE SAME UBE INDUSTRIES, LTD. (JP) 2000-01-05 EP disclosed