Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18124824 | 0.84 | CA1 (0.39) | CA1CA2CA12CA9 | |
| SCHEMBL7591871 | 0.75 | ACHE (0.36) | TSHRCA1CA2CA12CA9 | |
| SCHEMBL17236446 | 0.75 | CA2 (0.37) | TSHRLMNACA1CA2CA12 | |
| SCHEMBL20312448 | 0.75 | ALOX15 (0.36) | TSHRCA1CA2CA12CA9 | |
| SCHEMBL10018676 | 0.75 | CA1 (0.33) | CA1CA2CA12CA9CYP2A13 | |
| SCHEMBL7858626 | 0.75 | TSHR (0.45) | TSHRLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL29777948 | 0.75 | TAAR1 (0.35) | TSHRLMNA | |
| SCHEMBL7214927 | 0.72 | ALDH1A1 (0.36) | TSHRCA1CA2CA12CA9 | |
| SCHEMBL13714210 | 0.72 | CA12 (0.32) | CA1CA2CA12CA9 | |
| SCHEMBL7590428 | 0.71 | CA1 (0.43) | TSHRCA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| US-5849912-A | Biphenyl derivatives | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |