Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 8/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | EPOR | P19235 | 1/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17274480 | 1.00 | KIF11 (0.50) | KIF11KCNH2CPB2MMP2MMP9 | |
| SCHEMBL29422004 | 0.89 | MMP2 (0.52) | KIF11CPB2MMP2MMP9TLR2 | |
| SCHEMBL30100119 | 0.88 | FPR2 (0.50) | CPB2ITGB3ITGA2BFPR2 | |
| SCHEMBL1268928 | 0.86 | KIF11 (0.47) | KIF11MMP2MMP9TLR2 | |
| SCHEMBL7593135 | 0.85 | MMP9 (0.47) | CPB2MMP2MMP9ANPEPTLR2 | |
| SCHEMBL29964734 | 0.84 | KIF11 (0.50) | KIF11MMP2MMP9FPR2 | |
| SCHEMBL28326846 | 0.84 | KIF11 (0.50) | KIF11FPR2 | |
| SCHEMBL20191077 | 0.84 | MMP2 (0.42) | KIF11CPB2MMP2MMP9ANPEP | |
| SCHEMBL29964865 | 0.83 | KIF11 (0.46) | KIF11KCNH2ITGB3ITGA2B | |
| SCHEMBL30167975 | 0.83 | PTPN1 (0.45) | PRSS1PRSS2PRSS3FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624377-B1 | Lysosomal enzyme-cleavable antitumor drug conjugates | BRISTOL MYERS SQUIBB CO (US) | 2002-01-23 | — | — | EP | claimed |
| EP-0624377-A2 | Lysosomal enzyme-cleavable antitumor drug conjugates | Bristol-Myers Squibb Company (US) | 1994-11-17 | — | — | EP | claimed |
| EP-0624377-B1 | Lysosomal enzyme-cleavable antitumor drug conjugates | BRISTOL MYERS SQUIBB CO (US) | 2002-01-23 | — | — | EP | disclosed |
| EP-0624377-A2 | Lysosomal enzyme-cleavable antitumor drug conjugates | Bristol-Myers Squibb Company (US) | 1994-11-17 | — | — | EP | disclosed |