Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.57 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.57 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | GGT1 | P19440 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7897908 | 0.87 | HSD17B10 (0.52) | HSD17B10KDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL1868204 | 0.87 | KDM4E (0.63) | HSD17B10KDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL10593350 | 0.84 | PTGS2 (0.51) | HSD17B10KDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL4380299 | 0.84 | HSD17B10 (0.59) | HSD17B10KDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL11019069 | 0.84 | HSD17B10 (0.59) | HSD17B10KDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL2780216 | 0.84 | HSD17B10 (0.59) | HSD17B10KDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL1821600 | 0.84 | HSD17B10 (0.59) | HSD17B10KDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL15889886 | 0.83 | PTGS2 (0.65) | HSD17B10KDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL3667204 | 0.81 | HSD17B10 (0.65) | HSD17B10KDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL3807269 | 0.81 | HSD17B10 (0.56) | HSD17B10KDM4ELMNACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8658639-B2 | N-substituted-cyclic amino derivative | DAINIPPON SUMITOMO PHARMA CO., LTD (JP) | 2014-02-25 | — | — | US | disclosed |
| US-8658639-B2 | N-substituted-cyclic amino derivative | DAINIPPON SUMITOMO PHARMA CO., LTD (JP) | 2014-02-25 | — | — | US | disclosed |
| US-20120122773-A1 | N-SUBSTITUTED-CYCLIC AMINO DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-05-17 | — | — | US | disclosed |
| US-20100210694-A1 | NEW NO-DONOR ASPIRIN DERIVATIVES | NICOX S.A. (FR) | 2010-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122773-A1 | N-SUBSTITUTED-CYCLIC AMINO DERIVATIVE | REN, AGTR1, AGTR2 | HSD17B10 976/4885KDM4E 2147/4885LMNA 1723/4885 |
| US-20100210694-A1 | NEW NO-DONOR ASPIRIN DERIVATIVES | PTGIS, NOS2, NOS3 | HSD17B10 1604/4885KDM4E 2962/4885LMNA 3769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.