SCHEMBL760978

SCHEMBL760978

O=C(O)c1cnc2n(c1=O)CCS2

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 6/20 0.66
SMN1; SMN2 Q16637 6/20 0.66
MAPT P10636 5/20 0.66
L3MBTL1 Q9Y468 1/20 0.66
TSHR P16473 1/20 0.65
RECQL P46063 1/20 0.65
ALDH1A1 P00352 7/20 0.64
HPGD P15428 2/20 0.64
HSD17B10 Q99714 2/20 0.63
MAPK1 P28482 1/20 0.63
CYP1A2 P05177 1/20 0.61
CYP2C19 P33261 1/20 0.61
NPC1 O15118 4/20 0.59
TAAR1 Q96RJ0 1/20 0.59
HTT P42858 4/20 0.57
GAA P10253 1/20 0.57
NPSR1 Q6W5P4 1/20 0.57
KDM4E B2RXH2 2/20 0.56
LMNA P02545 1/20 0.56
STAT3 P40763 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18608538 0.90 ALDH1A1 (0.58) RAB9ASMN1; SMN2MAPTL3MBTL1TSHR
SCHEMBL5717597 0.87 MAPT (0.63) RAB9ASMN1; SMN2MAPTL3MBTL1TSHR
SCHEMBL13485754 0.86 RAB9A (0.69) RAB9ASMN1; SMN2MAPTL3MBTL1TSHR
SCHEMBL18583110 0.78 ALDH1A1 (0.55) RAB9ASMN1; SMN2MAPTL3MBTL1TSHR
SCHEMBL7358637 0.77 TSHR (0.48) RAB9ASMN1; SMN2MAPTL3MBTL1TSHR
SCHEMBL18608242 0.77 CYP1A2 (1.00) RAB9ASMN1; SMN2MAPTL3MBTL1TSHR
SCHEMBL18608260 0.76 ALDH1A1 (0.80) RAB9ASMN1; SMN2MAPTL3MBTL1TSHR
SCHEMBL18608249 0.76 ALDH1A1 (0.80) RAB9ASMN1; SMN2MAPTL3MBTL1TSHR
SCHEMBL18716374 0.76 ALDH1A1 (0.54) RAB9ASMN1; SMN2MAPTL3MBTL1TSHR
SCHEMBL18071573 0.76 RAB9A (0.54) RAB9ASMN1; SMN2MAPTL3MBTL1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190112316-A1 THIAZOLO[3,2-A] PYRIMIDINONE AND OTHER HETEROBICYCLIC PYRIMIDINONE COMPOUNDS FOR USE IN MEDICAL THERAPY LYSOSOMAL THERAPEUTICS INC (US) 2019-04-18 US disclosed
US-20190112316-A1 THIAZOLO[3,2-A] PYRIMIDINONE AND OTHER HETEROBICYCLIC PYRIMIDINONE COMPOUNDS FOR USE IN MEDICAL THERAPY LYSOSOMAL THERAPEUTICS INC (US) 2019-04-18 US disclosed
EP-3344625-A1 THIAZOLO(3,2-A) PYRIMIDINONE AND OTHER HETEROBICYCLIC PYRIMIDINONE COMPOUNDS FOR USE IN MEDICAL THERAPY Lysosomal Therapeutics Inc. (US) 2018-07-11 EP disclosed
EP-2200440-B1 ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS CRESTONE INC (US) 2017-07-19 EP disclosed
WO-2017040879-A1 THIAZOLO(3,2-A) PYRIMIDINONE AND OTHER HETEROBICYCLIC PYRIMIDINONE COMPOUNDS FOR USE IN MEDICAL THERAPY LYSOSOMAL THERAPEUTICS INC. (US) 2017-03-09 WO disclosed
WO-2017040879-A1 THIAZOLO(3,2-A) PYRIMIDINONE AND OTHER HETEROBICYCLIC PYRIMIDINONE COMPOUNDS FOR USE IN MEDICAL THERAPY LYSOSOMAL THERAPEUTICS INC. (US) 2017-03-09 WO disclosed
US-20120053345-A1 Indazole Compounds ABBOTT LABORATORIES (US) 2012-03-01 US disclosed
EP-2139887-A2 METALLOPROTEASE INHIBITORS CONTAINING A HETEROCYCLIC MOIETY Alantos Pharmaceuticals Holding, Inc. (US) 2010-01-06 EP disclosed
EP-1296972-B1 ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS AVENTIS PHARMA INC (US) 2009-12-23 EP disclosed
WO-2008109180-A2 METALLOPROTEASE INHIBITORS CONTAINING A HETEROCYCLIC MOIETY ALANTOS PHARMACEUTICALS HOLDING, INC. (US) 2008-09-12 WO disclosed
US-20040058937-A1 Heterocyclic mutilin esters and their use as antibacterials SMITHKLINE BEECHAM P.L.C. (GB) 2004-03-25 US disclosed
EP-1359908-A1 QUINOLINES AND NITROGENATED DERIVATIVES THEREOF SUBSTITUTED IN 4-POSITION BY A PIPERIDINE-CONTAINING MOIETY AND THEIR USE AS ANTIBACTERIAL AGENTS SMITHKLINE BEECHAM PLC (GB) 2003-11-12 EP disclosed
US-20030187020-A1 Chemical compounds AVENTISUB LLC 2003-10-02 US disclosed
EP-1309565-A1 HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 2003-05-14 EP disclosed
EP-1296972-A1 ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS Aventis Pharmaceuticals Inc. (US) 2003-04-02 EP disclosed
WO-2002056882-A1 QUINOLINES AND NITROGENATED DERIVAIVE THEREOF SUBSTITUTED IN 4-POSITION BY A PIPERIDINE-CONTAINING MOIETY AND THEIR USE AS ANTIBACTERIAL AGENTS SMITHKLINE BEECHAM P.L.C. (GB) 2002-07-25 WO disclosed
WO-2002012199-A1 HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS SMITHKLINE BEECHAM P.L.C. (GB) 2002-02-14 WO disclosed
WO-2001090101-A1 ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS AVENTIS PHARMACEUTICALS INC. (US) 2001-11-29 WO disclosed
EP-1091958-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2001-04-18 EP disclosed
WO-2000001692-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2000-01-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040058937-A1 Heterocyclic mutilin esters and their use as antibacterials MLN, MSH2, MRPL21 RAB9A 940/4885SMN1; SMN2 262/4885MAPT 3122/4885
US-20190112316-A1 THIAZOLO[3,2-A] PYRIMIDINONE AND OTHER HETEROBICYCLIC PYRIMIDINONE COMPOUNDS FOR USE IN MEDICAL THERAPY PARK7, GAA, TYMP RAB9A 2527/4885SMN1; SMN2 51/4885MAPT 116/4885
US-20030187020-A1 Chemical compounds CMA1, TPSB2, TPSG1 RAB9A 1607/4885SMN1; SMN2 3953/4885MAPT 1376/4885
US-20120053345-A1 Indazole Compounds CYP3A43, CYP3A7, UGT1A1 RAB9A 740/4885SMN1; SMN2 2854/4885MAPT 2375/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.