Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GLP1R | P43220 | 1/20 | 0.42 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.42 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6492223 | 0.84 | MAPT (0.51) | NPC1ALDH1A1TP53MAPTXBP1 | |
| SCHEMBL30697102 | 0.84 | JMJD6 (0.43) | NPC1ALDH1A1TP53MAPTXBP1 | |
| SCHEMBL20399682 | 0.84 | JMJD6 (0.43) | NPC1ALDH1A1TP53MAPTXBP1 | |
| SCHEMBL4018903 | 0.84 | THRB (0.43) | NPC1ALDH1A1TP53MAPTXBP1 | |
| SCHEMBL29664441 | 0.84 | THRB (0.43) | NPC1ALDH1A1TP53MAPTXBP1 | |
| SCHEMBL15968597 | 0.83 | CA12 (0.46) | NPC1ALDH1A1TP53MAPTXBP1 | |
| SCHEMBL31255330 | 0.82 | ALDH1A1 (0.44) | S1PR1S1PR3ALDH1A1MAPTHTT | |
| SCHEMBL12350328 | 0.82 | ALDH1A1 (0.44) | S1PR1S1PR3ALDH1A1MAPTHTT | |
| SCHEMBL17362538 | 0.81 | TARBP2 (0.42) | NPC1ALDH1A1TP53MAPTXBP1 | |
| SCHEMBL8692342 | 0.81 | ALDH1A1 (0.46) | NPC1ALDH1A1TP53MAPTXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12545662-B2 | MK2 inhibitors and uses thereof | XINTHERA, INC. (US) | 2026-02-10 | — | — | US | disclosed |
| US-12139462-B2 | Pyridinone MK2 inhibitors and uses thereof | XINTHERA, INC. (US) | 2024-11-12 | — | — | US | disclosed |
| US-11987574-B2 | MK2 inhibitors and uses thereof | XINTHERA, INC. (US) | 2024-05-21 | — | — | US | disclosed |
| EP-4367099-A1 | PYRIDINONE MK2 INHIBITORS AND USES THEREOF | Xinthera, Inc. (US) | 2024-05-15 | — | — | EP | disclosed |
| CN-117843565-A | Preparation method and application of pyridine compound | 南京正荣医药化学有限公司 | 2024-04-09 | — | — | CN | disclosed |
| CN-117651698-A | Pyridone MK2 inhibitors and uses thereof | 新特拉有限公司 | 2024-03-05 | — | — | CN | disclosed |
| EP-4313970-A1 | MK2 INHIBITORS AND USES THEREOF | Xinthera, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| US-20230382864-A1 | PYRIDINONE MK2 INHIBITORS AND USES THEREOF | XINTHERA, INC. | 2023-11-30 | — | — | US | disclosed |
| US-20230382864-A1 | PYRIDINONE MK2 INHIBITORS AND USES THEREOF | XINTHERA, INC. | 2023-11-30 | — | — | US | disclosed |
| US-20230382864-A1 | PYRIDINONE MK2 INHIBITORS AND USES THEREOF | XINTHERA, INC. | 2023-11-30 | — | — | US | disclosed |
| WO-2022212489-A1 | MK2 INHIBITORS AND USES THEREOF | XINTHERA, INC. (US) | 2022-10-06 | — | — | WO | disclosed |
| US-20020055639-A1 | Pyrazole derivatives as herbicides | NEBEL KURT (CH) | 2002-05-09 | — | — | US | disclosed |
| US-6274536-B1 | CROPS, AGRICULTURE; PRE- AND POSTEMERGENCE | SYNGENTA CROP PROTECTION, INC. | 2001-08-14 | — | — | US | disclosed |
| US-6204221-B1 | Herbicides | SYNGENTA CROP PROTECTION, INC. | 2001-03-20 | — | — | US | disclosed |
| CN-1250446-A | Pyrazole derivatives as herbicides | NOVARTIS AG (CH) | 2000-04-12 | — | — | CN | disclosed |
| EP-0966461-A1 | PYRAZOLE DERIVATIVES AS HERBICIDES | Novartis AG (CH) | 1999-12-29 | — | — | EP | disclosed |
| CN-1237166-A | Pyrazole derivatives useful as herbicides | NOVARTIS AG (CH) | 1999-12-01 | — | — | CN | disclosed |
| EP-0941222-A2 | PYRAZOLE DERIVATIVES USEFUL AS HERBICIDES | Novartis AG (CH) | 1999-09-15 | — | — | EP | disclosed |
| WO-1998042698-A1 | PYRAZOLE DERIVATIVES AS HERBICIDES | NOVARTIS AG (CH) | 1998-10-01 | — | — | WO | disclosed |
| WO-1998021199-A2 | PYRAZOLE DERIVATIVES USEFUL AS HERBICIDES | NOVARTIS AG (CH) | 1998-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12139462-B2 | Pyridinone MK2 inhibitors and uses thereof | ENPP2, PLP2, PDXK | S1PR1 1466/4885S1PR3 1847/4885NPC1 4025/4885 |
| US-11987574-B2 | MK2 inhibitors and uses thereof | MKNK2, ENPP2, MAPKAPK2 | S1PR1 2884/4885S1PR3 3328/4885NPC1 3556/4885 |
| US-20020055639-A1 | Pyrazole derivatives as herbicides | CBR3, HCN1, HCN2 | S1PR1 2549/4885S1PR3 1606/4885NPC1 693/4885 |
| US-20230382864-A1 | PYRIDINONE MK2 INHIBITORS AND USES THEREOF | ENPP2, PLP2, PDXK | S1PR1 1466/4885S1PR3 1847/4885NPC1 4025/4885 |
| US-12545662-B2 | MK2 inhibitors and uses thereof | NR3C2, NR2C2, AGTR2 | S1PR1 767/4885S1PR3 949/4885NPC1 1460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.