Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.58 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.58 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.58 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.58 |
| ▸ | SRC | P12931 | 3/20 | 0.46 |
| ▸ | TDP2 | O95551 | 7/20 | 0.45 |
| ▸ | IDO1 | P14902 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL145725 | 0.74 | FGFR1 (1.00) | FGFR1FGFR2FGFR4FGFR3SRC | |
| Cleistopholine SCHEMBL6358965 | 0.70 | ALDH1A1 (0.55) | TDP2L3MBTL1ALDH1A1TDP1KMT2A | |
| Onychine SCHEMBL8548579 | 0.70 | ALDH1A1 (0.55) | TDP2L3MBTL1ALDH1A1TDP1KMT2A | |
| Onychine SCHEMBL31040561 | 0.70 | ALDH1A1 (0.55) | TDP2L3MBTL1ALDH1A1TDP1KMT2A | |
| SCHEMBL17263271 | 0.70 | L3MBTL1 (0.45) | FGFR1FGFR2FGFR4FGFR3TDP2 | |
| SCHEMBL6408518 | 0.68 | TDP2 (0.55) | TDP2S100A4TDP1KMT2A | |
| SCHEMBL6407115 | 0.68 | TDP2 (0.55) | TDP2S100A4TDP1KMT2A | |
| SCHEMBL30775035 | 0.67 | L3MBTL1 (0.53) | TDP2IDO1L3MBTL1ALDH1A1HPGD | |
| SCHEMBL23235907 | 0.67 | ALDH1A1 (0.55) | TDP2L3MBTL1ALDH1A1POLBTDP1 | |
| SCHEMBL7991158 | 0.66 | NOS2 (0.43) | TDP2ALDH1A1S100A4KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350749-B1 | SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| EP-1057812-A1 | AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |