SCHEMBL7690463

SCHEMBL7690463

Cc1c(-c2ncc(Cl)cc2F)nn(C)c1C#N

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TGFBR1 P36897 5/20 0.34
PDE2A O00408 1/20 0.33
FPR2 P25090 1/20 0.32
PROKR1 Q8TCW9 1/20 0.32
GRM5 P41594 1/20 0.32
EGLN2 Q96KS0 1/20 0.32
HPGD P15428 1/20 0.32
HTT P42858 1/20 0.32
HSD17B10 Q99714 1/20 0.32
S1PR1 P21453 4/20 0.31
S1PR3 Q99500 4/20 0.31
S1PR2 O95136 1/20 0.31
LMNA P02545 2/20 0.31
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
PABPC1 P11940 1/20 0.31
TGFBR2 P37173 3/20 0.31
TRPM5 Q9NZQ8 1/20 0.31
SMO Q99835 1/20 0.31
CYP11B1 P15538 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7690605 0.80 HSD11B1 (0.39) PDE2AEGLN2MEN1KMT2ANPSR1
SCHEMBL7968440 0.77
SCHEMBL7691483 0.76 KDM1A (0.32) MEN1KMT2A
SCHEMBL7687299 0.76 GRM5 (0.35) TGFBR1PDE2AFPR2PROKR1GRM5
SCHEMBL7904400 0.74 SMO (0.39) PDE2AFPR2PROKR1GRM5HPGD
SCHEMBL7688652 0.74 GRM5 (0.38) PDE2AFPR2PROKR1GRM5HPGD
SCHEMBL7685178 0.74 NR3C1 (0.30)
SCHEMBL7907722 0.73 FPR2 (0.33) PDE2AFPR2PROKR1GRM5HPGD
SCHEMBL7687213 0.73 HTR5A (0.38) TGFBR1FPR2PROKR1GRM5HPGD
SCHEMBL7686737 0.72 PDE10A (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020055639-A1 Pyrazole derivatives as herbicides NEBEL KURT (CH) 2002-05-09 US disclosed
US-6204221-B1 Herbicides SYNGENTA CROP PROTECTION, INC. 2001-03-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020055639-A1 Pyrazole derivatives as herbicides CBR3, HCN1, HCN2 TGFBR1 3067/4885PDE2A 3898/4885FPR2 1791/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.