SCHEMBL7704538

SCHEMBL7704538

CN(CC(=O)[O-])C[C@H]1CCc2cc(OCCOc3ccccc3)ccc2[C@H]1c1ccccc1.[Na+]

nearest known ligand 0.68

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR2 known ✓ Q92731 2/20 0.41
NR3C1 known ✓ P04150 1/20 0.41
ADORA3 known ✓ P0DMS8 1/20 0.41
PTGS2 known ✓ P35354 1/20 0.41
PPARG known ✓ P37231 1/20 0.41
PDE4D known ✓ Q08499 1/20 0.41
SLC6A9 P48067 1/20 0.68
PPARD Q03181 9/20 0.48
PPARA Q07869 2/20 0.43
MTNR1A P48039 2/20 0.41
MTNR1B P49286 2/20 0.41
ESR1 P03372 5/20 0.41
MLNR O43193 1/20 0.41
NR1I2 O75469 1/20 0.41
CHRM2 P08172 1/20 0.41
ADRB1 P08588 1/20 0.41
ADRA2A P08913 1/20 0.41
CHRM1 P11229 1/20 0.41
DRD2 P14416 1/20 0.41
ADRA2B P18089 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lithium Ion SCHEMBL7704525 0.90 SLC6A9 (0.69) SLC6A9PPARDPPARAMTNR1AMTNR1B
Lithium Ion SCHEMBL7700187 0.89 SLC6A9 (0.70) SLC6A9PPARDMTNR1AMTNR1BGHSR
Org-25935 SCHEMBL7704305 0.87 SLC6A9 (0.85) SLC6A9PPARDMTNR1AMTNR1B
Org-25935 SCHEMBL7703028 0.87 SLC6A9 (0.85) SLC6A9PPARDMTNR1AMTNR1B
Lithium Ion SCHEMBL7711880 0.87 SLC6A9 (0.66) SLC6A9PPARDPPARAMTNR1AMTNR1B
Lithium Ion SCHEMBL7698462 0.86 SLC6A9 (0.69) SLC6A9PPARDPPARAMTNR1AMTNR1B
Lithium Ion SCHEMBL7704091 0.86 SLC6A9 (0.69) SLC6A9MTNR1AMTNR1BESR1ESR2
Hydrochloric Acid SCHEMBL7703283 0.86 SLC6A9 (0.78) SLC6A9PPARDPPARAMTNR1AMTNR1B
SCHEMBL1761264 0.83 SLC6A9 (0.81) SLC6A9PPARDPPARAMTNR1AMTNR1B
SCHEMBL7708980 0.82 SLC6A9 (0.82) SLC6A9PPARDMTNR1AMTNR1BGHSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1100769-B1 AMINOMETHYLCARBOXYLIC ACID DERIVATIVES AKZO NOBEL NV (NL) 2002-12-04 EP disclosed
US-6410592-B1 THERAPY FOR CENTRAL NERVOUS SYSTEM DISORDERS, PSYCHOLOGICAL DISORDERS AKZO NOBEL N.V. (NL) 2002-06-25 US disclosed