Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MT-CO2 | P00403 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.47 |
| ▸ | MAOB | P27338 | 4/20 | 0.45 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | FABP2 | P12104 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30192791 | 1.00 | MT-CO2 (0.47) | MT-CO2PTGS1PTGS2MAOBAPP | |
| SCHEMBL24875457 | 1.00 | MT-CO2 (0.47) | MT-CO2PTGS1PTGS2MAOBAPP | |
| SCHEMBL14798202 | 0.87 | MT-CO2 (0.47) | MT-CO2PTGS1PTGS2MAOBAPP | |
| SCHEMBL31560842 | 0.85 | PTGS1 (0.50) | MT-CO2PTGS1PTGS2MAOBAPP | |
| SCHEMBL30192767 | 0.84 | PTGS2 (0.44) | PTGS1PTGS2MAOBAPPCYP2C19 | |
| SCHEMBL5948065 | 0.84 | PTGS2 (0.44) | PTGS1PTGS2MAOBAPPCYP2C19 | |
| SCHEMBL7708885 | 0.84 | HDAC1 (0.42) | PTGS2APPCYP2C19HDAC1HDAC6 | |
| Acetic Acid SCHEMBL21808210 | 0.83 | PTGS1 (0.47) | MT-CO2PTGS1PTGS2MAOBAPP | |
| SCHEMBL10967797 | 0.82 | MT-CO2 (0.55) | MT-CO2PTGS1PTGS2MAOBAPP | |
| SCHEMBL19392984 | 0.82 | MT-CO2 (0.55) | MT-CO2PTGS1PTGS2MAOBAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776398-B1 | SUBSTITUTED PYRAZOLYL-BASED UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | MEDIFRON DBT INC (KR) | 2020-09-02 | — | — | EP | disclosed |
| EP-2880015-B1 | MULTITARGET FAAH AND COX INHIBITORS AND THERAPEUTICAL USES THEREOF | FOND ST ITALIANO TECNOLOGIA (IT) | 2017-09-27 | — | — | EP | disclosed |
| EP-2880015-B1 | MULTITARGET FAAH AND COX INHIBITORS AND THERAPEUTICAL USES THEREOF | FOND ST ITALIANO TECNOLOGIA (IT) | 2017-09-27 | — | — | EP | disclosed |
| US-9630914-B2 | Multitarget FAAH and COX inhibitors and therapeutical uses thereof | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2017-04-25 | — | — | US | disclosed |
| US-9630914-B2 | Multitarget FAAH and COX inhibitors and therapeutical uses thereof | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2017-04-25 | — | — | US | disclosed |
| US-9630914-B2 | Multitarget FAAH and COX inhibitors and therapeutical uses thereof | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2017-04-25 | — | — | US | disclosed |
| US-9624209-B2 | Substituted phenylureas and phenylamides as vanilloid receptor ligands | GRUENENTHAL GMBH (DE) | 2017-04-18 | — | — | US | disclosed |
| US-20150203447-A1 | MULTITARGET FAAH AND COX INHIBITORS AND THERAPEUTICAL USES THEREOF | Fondazione Istituti Italiano di Tecnologia (IT) | 2015-07-23 | — | — | US | disclosed |
| US-20150203447-A1 | MULTITARGET FAAH AND COX INHIBITORS AND THERAPEUTICAL USES THEREOF | Fondazione Istituti Italiano di Tecnologia (IT) | 2015-07-23 | — | — | US | disclosed |
| US-20150203447-A1 | MULTITARGET FAAH AND COX INHIBITORS AND THERAPEUTICAL USES THEREOF | Fondazione Istituti Italiano di Tecnologia (IT) | 2015-07-23 | — | — | US | disclosed |
| US-20130079377-A1 | Aryl or N-heteroaryl Substituted Methanesulfonamide Derivatives as Vanilloid Receptor Ligands | GRUENENTHAL GMBH (DE) | 2013-03-28 | — | — | US | disclosed |
| US-20130079377-A1 | Aryl or N-heteroaryl Substituted Methanesulfonamide Derivatives as Vanilloid Receptor Ligands | GRUENENTHAL GMBH (DE) | 2013-03-28 | — | — | US | disclosed |
| US-20130079377-A1 | Aryl or N-heteroaryl Substituted Methanesulfonamide Derivatives as Vanilloid Receptor Ligands | GRUENENTHAL GMBH (DE) | 2013-03-28 | — | — | US | disclosed |
| US-20120258946-A1 | Substituted Phenylureas and Phenylamides as Vanilloid Receptor Ligands | GRUENENTHAL GMBH (DE) | 2012-10-11 | — | — | US | disclosed |
| EP-1229034-B1 | Nicotinamide derivatives and their mimetics as inhibitors of PDE4 isozymes | PFIZER PROD INC (US) | 2005-04-13 | — | — | EP | disclosed |
| EP-0100120-B1 | IMPROVEMENT IN THE PROCESS FOR PREPARING BIARYL COMPOUNDS VIA COUPLING OF AN ARYLAMINE WITH AN ARENE | Nobel Chemicals AB (SE) | 1988-02-03 | — | — | EP | disclosed |
| US-4710581-A | Nucleophilic substitution process | ETHYL CORPORATION (US) | 1987-12-01 | — | — | US | disclosed |
| US-4581463-A | Nucleophilic substitution process combined with additional reaction steps | ETHYL CORPORATION (US) | 1986-04-08 | — | — | US | disclosed |
| US-4542233-A | Process for preparing biaryl compounds via coupling of an arylamine with an arene | BIASCHIM S.P.A. (IT) | 1985-09-17 | — | — | US | disclosed |
| EP-0100120-A1 | Improvement in the process for preparing biaryl compounds via coupling of an arylamine with an arene | Nobel Chemicals AB (SE) | 1984-02-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150203447-A1 | MULTITARGET FAAH AND COX INHIBITORS AND THERAPEUTICAL USES THEREOF | FAAH, FAAH2, CNR2 | MT-CO2 1644/4885PTGS1 7/4885PTGS2 11/4885 |
| US-20130079377-A1 | Aryl or N-heteroaryl Substituted Methanesulfonamide Derivatives as Vanilloid Receptor Ligands | TRPV1, TRPV3, TRPA1 | MT-CO2 2505/4885PTGS1 710/4885PTGS2 772/4885 |
| US-20120258946-A1 | Substituted Phenylureas and Phenylamides as Vanilloid Receptor Ligands | TRPV1, TRPV5, TRPV6 | MT-CO2 4515/4885PTGS1 1476/4885PTGS2 1336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.