Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL809315 | 0.98 | TGFBR1 (0.32) | TGFBR1KDM4EALDH1A1 | |
| Bromide SCHEMBL4456365 | 0.96 | DNM1 (0.32) | TGFBR1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL201995 | 0.96 | THRB (0.32) | TGFBR1KDM4EALDH1A1 | |
| SCHEMBL9451788 | 0.82 | TGFBR1 (0.33) | TGFBR1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL782053 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL717635 | 0.81 | THRB (0.33) | TGFBR1KDM4EALDH1A1 | |
| Iodide SCHEMBL27449413 | 0.81 | TGFBR1 (0.32) | TGFBR1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL10949727 | 0.79 | TGFBR1 (0.33) | TGFBR1 | |
| SCHEMBL151383 | 0.79 | DNM1 (0.39) | — | |
| Hydrochloric Acid SCHEMBL21801687 | 0.76 | SLC22A1 (0.31) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5525356-A | Amphoteric N-substituted acrylamide hydrogel and method | MEDTRONIC, INC. (US) | 1996-06-11 | — | — | US | claimed |
| EP-0481042-B1 | AMPHOTERIC HYDROGEL FOR MEDICAL DEVICES | MEDTRONIC INC (US) | 1995-07-12 | — | — | EP | claimed |
| US-5264125-A | Cationic or anionic addition monomer with crosslinking monomer and a diluent for nonporous membranes | IONICS' INCORPORATED (US) | 1993-11-23 | — | — | US | claimed |
| EP-0481042-A1 | AMPHOTERIC HYDROGEL FOR MEDICAL DEVICES. | MEDTRONIC INC (US) | 1992-04-22 | — | — | EP | claimed |
| WO-1991015250-A1 | AMPHOTERIC HYDROGEL FOR MEDICAL DEVICES | MEDTRONIC, INC. (US) | 1991-10-17 | — | — | WO | claimed |
| US-6380456-B1 | URINE ABSORPTION | THE PROCTOR & GAMBLE COMPANY | 2002-04-30 | — | — | US | disclosed |
| US-6258996-B1 | MULTILAYER; ABSORPTION OF URINE | THE PROCTER & GAMBLE COMPANY | 2001-07-10 | — | — | US | disclosed |
| EP-0964894-A1 | MIXED-BED ION-EXCHANGE HYDROGEL-FORMING POLYMER COMPOSITIONS AND ABSORBENT MEMBERS COMPRISING RELATIVELY HIGH CONCENTRATIONS OF THESE COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |
| WO-1998037149-A1 | MIXED-BED ION-EXCHANGE HYDROGEL-FORMING POLYMER COMPOSITIONS AND ABSORBENT MEMBERS COMPRISING RELATIVELY HIGH CONCENTRATIONS OF THESE COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1998-08-27 | — | — | WO | disclosed |
| US-5525356-A | Amphoteric N-substituted acrylamide hydrogel and method | MEDTRONIC, INC. (US) | 1996-06-11 | — | — | US | disclosed |
| US-5525356-A | Amphoteric N-substituted acrylamide hydrogel and method | MEDTRONIC, INC. (US) | 1996-06-11 | — | — | US | disclosed |
| EP-0481042-B1 | AMPHOTERIC HYDROGEL FOR MEDICAL DEVICES | MEDTRONIC INC (US) | 1995-07-12 | — | — | EP | disclosed |
| EP-0586566-A4 | SALT TOLERANT SUPER ABSORBENTS. | MASSACHUSETTS INST TECHNOLOGY (US) | 1994-11-02 | — | — | EP | disclosed |
| EP-0586566-A1 | SALT TOLERANT SUPER ABSORBENTS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1994-03-16 | — | — | EP | disclosed |
| US-5274018-A | Salt tolerant super absorbents | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1993-12-28 | — | — | US | disclosed |
| WO-1992020735-A1 | SALT TOLERANT SUPER ABSORBENTS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1992-11-26 | — | — | WO | disclosed |
| EP-0481042-A1 | AMPHOTERIC HYDROGEL FOR MEDICAL DEVICES. | MEDTRONIC INC (US) | 1992-04-22 | — | — | EP | disclosed |
| EP-0481042-A1 | AMPHOTERIC HYDROGEL FOR MEDICAL DEVICES. | MEDTRONIC INC (US) | 1992-04-22 | — | — | EP | disclosed |
| WO-1991015250-A1 | AMPHOTERIC HYDROGEL FOR MEDICAL DEVICES | MEDTRONIC, INC. (US) | 1991-10-17 | — | — | WO | disclosed |
| WO-1991015250-A1 | AMPHOTERIC HYDROGEL FOR MEDICAL DEVICES | MEDTRONIC, INC. (US) | 1991-10-17 | — | — | WO | disclosed |