SCHEMBL7717550

SCHEMBL7717550

Nc1cc2ccccc2cc1C(=O)[O-].[Na+]

nearest known ligand 0.66

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 known ✓ P00918 1/20 0.40
CA4 known ✓ P22748 1/20 0.40
IDO1 P14902 1/20 0.66
KDM4E B2RXH2 4/20 0.45
ALDH1A1 P00352 4/20 0.45
HPGD P15428 2/20 0.45
TDP1 Q9NUW8 2/20 0.44
POLB P06746 2/20 0.44
GAA P10253 2/20 0.42
MAPT P10636 2/20 0.42
MEN1 O00255 1/20 0.42
MITF O75030 1/20 0.42
KMT2A Q03164 1/20 0.42
NCOA1 Q15788 1/20 0.42
NCOA3 Q9Y6Q9 1/20 0.42
IKBKB O14920 2/20 0.41
IRAK4 Q9NWZ3 1/20 0.38
GFER P55789 1/20 0.37
NGLY1 Q96IV0 1/20 0.37
GPR35 Q9HC97 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29904664 0.85 KDM4E (0.54) IDO1KDM4EALDH1A1HPGDTDP1
SCHEMBL30447178 0.81 IDO1 (0.48) IDO1KDM4EALDH1A1HPGDTDP1
Lithium Ion SCHEMBL12983973 0.81 IDO1 (0.48) IDO1KDM4EALDH1A1HPGDTDP1
Potassium Ion SCHEMBL10348258 0.81 IDO1 (0.48) IDO1KDM4EALDH1A1HPGDTDP1
SCHEMBL8006520 0.80 IDO1 (0.66) IDO1KDM4EALDH1A1HPGDTDP1
SCHEMBL197490 0.79 IDO1 (1.00) IDO1KDM4EALDH1A1HPGDTDP1
SCHEMBL2205716 0.79 IDO1 (0.70) IDO1KDM4EALDH1A1HPGDTDP1
SCHEMBL8006518 0.79 IDO1 (1.00) IDO1KDM4EALDH1A1HPGDTDP1
SCHEMBL29475880 0.79 IDO1 (1.00) IDO1KDM4EALDH1A1HPGDTDP1
SCHEMBL9017418 0.78 KDM4E (0.57) KDM4EALDH1A1HPGDTDP1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6451607-B1 WET TRANSFER SWAB OR SPONGE; INDICATOR FOR COLORIMETRIC ANALYSIS; DIAGNOSES OF INFECTIONS LITMUS CONCEPTS, INC. 2002-09-17 US disclosed
WO-1999057562-A1 EXTERNAL DRIED-REAGENT CONTROL FOR ANALYTICAL TEST DEVICES LITMUS CONCEPTS, INC. (US) 1999-11-11 WO disclosed
US-4026916-A Terminal amine-containing polypivalolactone E. I. DU PONT DE NEMOURS & COMPANY (US) 1977-05-31 US disclosed