Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7736595 | 0.85 | ALDH1A1 (0.40) | MAPTMAPK1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6474949 | 0.83 | HTR1A (0.52) | MAPTMAPK1DRD2ALDH1A1HTT | |
| SCHEMBL7732078 | 0.80 | DRD2 (0.50) | MAPTMAPK1DRD2ALDH1A1HTT | |
| SCHEMBL27435293 | 0.74 | MAPT (0.50) | MAPTMAPK1DRD2ALDH1A1HTT | |
| SCHEMBL7736577 | 0.73 | HTR1A (0.54) | MAPTMAPK1DRD2SMN1; SMN2LMNA | |
| SCHEMBL7607947 | 0.72 | LMNA (0.51) | MAPTMAPK1DRD2ALDH1A1SMN1; SMN2 | |
| SCHEMBL7607699 | 0.70 | ADRB2 (0.54) | MAPTDRD2ALDH1A1 | |
| SCHEMBL6930796 | 0.70 | DRD2 (0.59) | MAPTMAPK1DRD2ALDH1A1HTT | |
| SCHEMBL6933603 | 0.70 | ADRA1D (0.61) | MAPTDRD2ALDH1A1TSHR | |
| SCHEMBL5884404 | 0.69 | KMT2A (0.46) | MAPTALDH1A1HTTSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399614-B1 | TREATING NEUROMUSCULAR DYSFUNCTION OF LOWER URINARY TRACT VIA PERIPHERAL OR CENTRAL NERVOUS SYSTEM; SEROTONIN RECEPTOR ANTAGONIST | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2002-06-04 | — | — | US | disclosed |