Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7759855 | 0.92 | CCR3 (0.58) | SIGMAR1CCR3KMT2ADRD2 | |
| SCHEMBL7756765 | 0.88 | SIGMAR1 (0.58) | SIGMAR1POLBHTR1A | |
| SCHEMBL8108851 | 0.84 | CCR3 (0.59) | SIGMAR1CCR3HTR1AKCNH2 | |
| SCHEMBL8109164 | 0.82 | SIGMAR1 (0.51) | SIGMAR1ADRA1DADRA1AADRA1BKMT2A | |
| SCHEMBL7756722 | 0.82 | SIGMAR1 (0.53) | SIGMAR1POLB | |
| SCHEMBL9449597 | 0.81 | SIGMAR1 (0.55) | SIGMAR1LMNAHTR1A | |
| SCHEMBL9230596 | 0.81 | SIGMAR1 (0.54) | SIGMAR1POLB | |
| SCHEMBL9449807 | 0.80 | DRD2 (0.46) | ADRA1AKMT2AHTR1ADRD2KCNH2 | |
| SCHEMBL9449641 | 0.80 | ADRA1D (0.51) | ADRA1DADRA1AADRA1BPOLBHTR1A | |
| Hydrochloric Acid SCHEMBL9449688 | 0.79 | ADRA1D (0.61) | ADRA1DADRA1AADRA1BHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5512569-A | SIGMA RECEPTOR DISORDERS; PSYCHOLOGICAL DISORDERS | ADIR ET COMPAGNIE (FR) | 1996-04-30 | — | — | US | claimed |
| EP-0673934-B1 | Aminoalkyl benzothiazolinones, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-04-25 | — | — | EP | disclosed |
| US-5512569-A | SIGMA RECEPTOR DISORDERS; PSYCHOLOGICAL DISORDERS | ADIR ET COMPAGNIE (FR) | 1996-04-30 | — | — | US | disclosed |
| EP-0673934-A1 | Aminoalkyl benzothiazolinones, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-09-27 | — | — | EP | disclosed |