Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 2/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9055313 | 0.79 | GPR84 (0.56) | GPR84KDM4EMAPK1ATMP2RX4 | |
| SCHEMBL4043114 | 0.78 | LMNA (0.46) | AHRKDM4EMAPK1ATMP2RX4 | |
| SCHEMBL7770745 | 0.71 | LMNA (0.46) | AHRGPR84KDM4EP2RX4KMT2A | |
| SCHEMBL7765648 | 0.70 | AHR (0.41) | AHRKDM4EMAPK1ATMP2RX4 | |
| SCHEMBL7769094 | 0.67 | AHR (0.41) | AHRKDM4EMAPK1ATMP2RY6 | |
| SCHEMBL1637925 | 0.63 | AKR1C3 (0.47) | ALDH1A1KMT2AMEN1NPSR1HTT | |
| SCHEMBL1128324 | 0.62 | AHR (0.50) | AHRKDM4EMAPK1ATMALDH1A1 | |
| SCHEMBL56864 | 0.61 | PTK2B (0.50) | ALDH1A1KMT2AMEN1HTTMAPT | |
| SCHEMBL9682799 | 0.61 | TSHR (0.44) | KDM4EMAPK1ALDH1A1KMT2AMEN1 | |
| SCHEMBL3277352 | 0.61 | ALDH1A1 (0.39) | KDM4EMAPK1ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726265-B1 | 10-Aminoaliphatyl-dibenz(b,f)oxepins with antineurodegenarative activity | NOVARTIS AG (CH) | 2001-07-25 | — | — | EP | disclosed |
| EP-0726265-A1 | 10-Aminoaliphatyl-dibenz(b,f)oxepins with antineurodegenarative activity | CIBA-GEIGY AG (CH) | 1996-08-14 | — | — | EP | disclosed |