Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.30 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.30 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.30 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7777489 | 0.89 | GAA (0.35) | RAB9ATSHRALDH1A1ACHEHTT | |
| SCHEMBL7778618 | 0.89 | RAB9A (0.33) | RAB9AALDH1A1 | |
| SCHEMBL7777487 | 0.86 | TSHR (0.32) | RAB9ATSHRALDH1A1CNR1CNR2 | |
| SCHEMBL7771287 | 0.81 | NAAA (0.35) | RAB9ATSHRMAPK1KMT2AMEN1 | |
| SCHEMBL7713617 | 0.80 | ALDH1A1 (0.46) | TSHRMAPK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL7778631 | 0.78 | TSHR (0.35) | RAB9ATSHRMAPK1KMT2AMEN1 | |
| SCHEMBL22561224 | 0.78 | ACHE (0.43) | TSHRKMT2AMEN1ALDH1A1ACHE | |
| SCHEMBL16303440 | 0.78 | TSHR (0.35) | RAB9ATSHRMAPK1KMT2AMEN1 | |
| SCHEMBL1415972 | 0.78 | TSHR (0.35) | RAB9ATSHRMAPK1KMT2AMEN1 | |
| SCHEMBL7950916 | 0.77 | MEN1 (0.42) | RAB9ATSHRMAPK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |