Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 12/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 11/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7070543 | 0.85 | MTNR1A (0.50) | MTNR1AMTNR1BKDM4EMAOAALDH1A1 | |
| SCHEMBL6905932 | 0.84 | CTSV (0.41) | KDM4EMAOAALDH1A1HPGDMCL1 | |
| SCHEMBL7072937 | 0.82 | KIF11 (0.36) | MTNR1AMTNR1BKDM4EMAOAALDH1A1 | |
| SCHEMBL7779239 | 0.76 | ALOX15 (0.48) | KDM4EALDH1A1 | |
| SCHEMBL7781300 | 0.75 | NR1I2 (0.33) | KDM4EMAOAALDH1A1HPGDMCL1 | |
| SCHEMBL7069437 | 0.75 | KDM4E (0.42) | MTNR1AMTNR1BKDM4EMAOAALDH1A1 | |
| SCHEMBL7977146 | 0.72 | TP53 (0.38) | KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL7980657 | 0.72 | HTR1D (0.35) | MTNR1AMTNR1B | |
| SCHEMBL7068692 | 0.71 | ADRB2 (0.39) | KDM4EALDH1A1HPGD | |
| SCHEMBL7778752 | 0.71 | KDM4E (0.38) | KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1128845-A1 | COMBINATIONS COMPRISING A BETA-AGONIST AND A FURTHER ANTDIABETIC AGENT | SMITHKLINE BEECHAM PLC (GB) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027434-A1 | COMBINATIONS COMPRISING A BETA-AGONIST AND A FURTHER ANTIDIABETIC AGENT | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-05-18 | — | — | WO | disclosed |