Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5667519 | 1.00 | TSHR (0.42) | TSHRCASP1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8888752 | 0.92 | TSHR (0.40) | TSHRCASP1ALDH1A1LMNAKDM4E | |
| SCHEMBL7782299 | 0.74 | PDE7A (0.45) | ALDH1A1PDE7APDE7BLMNAKDM4E | |
| SCHEMBL30910102 | 0.68 | PDE7A (0.51) | TSHRCASP1ALDH1A1PDE7APDE7B | |
| SCHEMBL3150851 | 0.68 | PDE7A (0.51) | TSHRCASP1ALDH1A1PDE7APDE7B | |
| SCHEMBL9436260 | 0.68 | ALDH1A1 (0.41) | TSHRCASP1ALDH1A1PDE7APDE7B | |
| SCHEMBL7783672 | 0.67 | LMNA (0.43) | ALDH1A1SMN1; SMN2LMNAKDM4EMAPT | |
| SCHEMBL699273 | 0.65 | LMNA (0.65) | ALDH1A1PDE7APDE7BLMNAKDM4E | |
| SCHEMBL29367625 | 0.65 | LMNA (0.65) | ALDH1A1PDE7APDE7BLMNAKDM4E | |
| SCHEMBL16634744 | 0.60 | L3MBTL1 (0.55) | SMN1; SMN2LMNAKDM4EMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186564-B2 | Polynucleotides encoding novel cysteine proteases of the calpain superfamily, CAN-12v1 and CAN-12v2. | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-03-06 | — | — | US | disclosed |
| US-20060183196-A1 | Polynucleotide encoding a novel cysteine protease of the calpain superfamily, CAN-12, and variants thereof | CHEN JIAN | 2006-08-17 | — | — | US | disclosed |
| EP-1567642-A4 | POLYNUCLEOTIDE ENCODING A NOVEL CYSTEINE PROTEASE OF THE CALPAIN SUPERFAMILY, CAN-12, AND VARIANTS THEREOF | BRISTOL MYERS SQUIBB CO (US) | 2006-02-08 | — | — | EP | disclosed |
| EP-1572926-A2 | POLYNUCLEOTIDE ENCODING A NOVEL CYSTEINE PROTEASE OF THE CALPAIN SUPERFAMILY, PROTEASE-42 | Bristol-Myers Squibb Company (US) | 2005-09-14 | — | — | EP | disclosed |
| EP-1567642-A2 | POLYNUCLEOTIDE ENCODING A NOVEL CYSTEINE PROTEASE OF THE CALPAIN SUPERFAMILY, CAN-12, AND VARIANTS THEREOF | Bristol-Myers Squibb Company (US) | 2005-08-31 | — | — | EP | disclosed |
| US-20040014093-A1 | Polynucleotide encoding a novel cysteine protease of the calpain superfamily, Protease-42 | BRISTOL-MYERS SQUIBB COMPANY | 2004-01-22 | — | — | US | disclosed |
| WO-2003078594-A2 | POLYNUCLEOTIDE ENCODING A NOVEL CYSTEINE PROTEASE OF THE CALPAIN SUPERFAMILY, PROTEASE-42 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-09-25 | — | — | WO | disclosed |
| US-20030114373-A1 | Polynucleotide encoding a novel cysteine protease of the calpain superfamily, CAN-12, and variants thereof | BRISTOL-MYERS SQUIBB COMPANY | 2003-06-19 | — | — | US | disclosed |
| WO-2002088303-A2 | POLYNUCLEOTIDE ENCODING A NOVEL CYSTEINE PROTEASE OF THE CALPAIN SUPERFAMILY, CAN-12, AND VARIANTS THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014093-A1 | Polynucleotide encoding a novel cysteine protease of the calpain superfamily, Protease-42 | CAPNS1, CAPN1, CAPN2 | TSHR 3797/4885CASP1 2404/4885ALDH1A1 4710/4885 |
| US-20060183196-A1 | Polynucleotide encoding a novel cysteine protease of the calpain superfamily, CAN-12, and variants thereof | CAPN9, CAPN1, CAPNS1 | TSHR 3628/4885CASP1 3139/4885ALDH1A1 4707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.