SCHEMBL7801737

SCHEMBL7801737

Cc1ncc(N)n1-c1c(Cl)cc(C(F)(F)F)cc1Cl

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRB3 P28472 15/20 0.48
GABRA2 P47869 15/20 0.48
GABRB2 P47870 15/20 0.48
GABRP O00591 11/20 0.48
GABRD O14764 11/20 0.48
GABRA1 P14867 11/20 0.48
GABRB1 P18505 11/20 0.48
GABRG2 P18507 11/20 0.48
GABRA5 P31644 11/20 0.48
GABRA3 P34903 11/20 0.48
GABRA4 P48169 11/20 0.48
GABRE P78334 11/20 0.48
GABRA6 Q16445 11/20 0.48
GABRG1 Q8N1C3 11/20 0.48
GABRG3 Q99928 11/20 0.48
GABRQ Q9UN88 11/20 0.48
KDM4E B2RXH2 1/20 0.40
ALDH1A1 P00352 1/20 0.40
POLB P06746 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8446536 0.72 GABRB3 (0.45) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL6168749 0.71 GABRB3 (0.68) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL7800364 0.71 GABRP (0.48) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL10371826 0.70 GABRB3 (0.53) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL7792831 0.69 GABRB3 (0.47) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL10628680 0.69 GABRB3 (0.59) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL8890432 0.68 GABRA2 (0.43) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL6975980 0.68 GABRB3 (0.70) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL9723055 0.68 GABRA2 (0.45) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL166766 0.68 ALDH1A1 (0.53) KDM4EALDH1A1POLBSMN1; SMN2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0484165-B1 Pesticidal 1-arylimidazoles AVENTIS CROPSCIENCE SA (FR) 2001-08-16 EP disclosed
CN-1045710-C Pesticidal 1-arylimidazoles RHONE POULENC AGROCHIMIE (FR) 1999-10-20 CN disclosed
EP-0396427-B1 Pesticidal 1-arylimidazoles RHONE POULENC AGROCHIMIE (FR) 1995-09-13 EP disclosed
US-5223525-A Pesticidal 1-arylimidazoles RHONE-POULENC AG COMPANY (US) 1993-06-29 US disclosed
EP-0484165-A1 Pesticidal 1-arylimidazoles RHONE-POULENC AGROCHIMIE (FR) 1992-05-06 EP disclosed
EP-0396427-A1 Pesticidal 1-arylimidazoles RHONE-POULENC AGROCHIMIE (FR) 1990-11-07 EP disclosed