Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 5/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7807904 | 0.80 | CYP11B2 (0.46) | TBXAS1HDAC6CYP11B2HDAC1ALDH1A1 | |
| SCHEMBL7803002 | 0.79 | TBXAS1 (0.70) | TBXAS1CYP11B2MAPTCYP2D6 | |
| SCHEMBL7811888 | 0.78 | CAMK2D (0.51) | TBXAS1CYP11B2 | |
| SCHEMBL9282505 | 0.78 | TBXAS1 (0.51) | TBXAS1HDAC6CYP11B2HDAC1ALDH1A1 | |
| SCHEMBL8544033 | 0.78 | TBXAS1 (0.74) | TBXAS1HDAC6ALDH1A1MAPTKDM4E | |
| SCHEMBL7803240 | 0.77 | ALDH1A1 (0.48) | CYP11B2ALDH1A1 | |
| SCHEMBL7803024 | 0.75 | TBXAS1 (0.53) | TBXAS1HDAC6CYP11B2MAPTCYP2D6 | |
| SCHEMBL9237199 | 0.74 | TBXAS1 (0.58) | TBXAS1ALDH1A1KDM4E | |
| SCHEMBL7803168 | 0.74 | TBXAS1 (0.54) | TBXAS1HDAC6CYP11B2MAPTCYP2D6 | |
| SCHEMBL7803155 | 0.72 | CAMK2D (0.52) | TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0949259-B1 | N-HYDROXYUREA DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2001-06-20 | — | — | EP | disclosed |
| US-6184238-B1 | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-02-06 | — | — | US | disclosed |
| EP-0949259-A1 | N-HYDROXYUREA DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-10-13 | — | — | EP | disclosed |