Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7824877 | 0.84 | MAPT (0.39) | L3MBTL1SMN1; SMN2MAPK1RAB9ANPC1 | |
| SCHEMBL8799546 | 0.83 | ALDH1A1 (0.39) | L3MBTL1SMN1; SMN2MAPK1RAB9ANPC1 | |
| SCHEMBL7827083 | 0.83 | TYK2 (0.47) | L3MBTL1SMN1; SMN2RAB9ALMNAPOLB | |
| SCHEMBL7817437 | 0.83 | ALDH1A1 (0.39) | L3MBTL1SMN1; SMN2MAPK1LMNAPOLB | |
| SCHEMBL7824213 | 0.79 | RAB9A (0.41) | L3MBTL1SMN1; SMN2RAB9ANPC1CRHBP | |
| SCHEMBL8808952 | 0.79 | CRHBP (0.43) | TDP1L3MBTL1SMN1; SMN2MAPK1RAB9A | |
| SCHEMBL16583563 | 0.78 | TDP1 (0.60) | TDP1L3MBTL1SMN1; SMN2MAPK1RAB9A | |
| SCHEMBL7816325 | 0.76 | MAOB (0.38) | L3MBTL1SMN1; SMN2RAB9ANPC1GAA | |
| SCHEMBL7827508 | 0.76 | GPR35 (0.50) | SMN1; SMN2MAPK1ALDH1A1PDK1PDK2 | |
| SCHEMBL8799382 | 0.76 | TYK2 (0.37) | SMN1; SMN2RAB9ALMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757682-B1 | BENZOFURAN DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION | FUJISAWA PHARMACEUTICAL CO (JP) | 2001-06-20 | — | — | EP | disclosed |
| EP-0730595-A4 | IMIDAZOLINOBENZODIAZEPINES | MERCK & CO INC (US) | 1997-07-16 | — | — | EP | disclosed |
| EP-0730595-A1 | IMIDAZOLINOBENZODIAZEPINES | MERCK & CO. INC. (US) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995029907-A1 | BENZOFURAN DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-09 | — | — | WO | disclosed |