Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.59 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.59 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.59 |
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 0.59 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.59 |
| ▸ | NR3C1 known ✓ | P04150 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 6/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | MLNR | O43193 | 1/20 | 0.59 |
| ▸ | MMP1 | P03956 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7829064 | 0.84 | MAPT (0.57) | MAPTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL7830987 | 0.77 | CYP19A1 (0.53) | MAPTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL7830984 | 0.77 | TBXA2R (0.56) | MAPTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL11315551 | 0.77 | MEN1 (0.58) | MAPTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL3845000 | 0.77 | MAPT (0.58) | MAPTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL10337156 | 0.77 | HTT (0.60) | MAPTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL6725208 | 0.77 | TBXA2R (0.55) | MAPTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL28738308 | 0.77 | TBXA2R (0.62) | MAPTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL9011400 | 0.76 | CASP1 (0.47) | KMT2ALMNASMN1; SMN2MAPK1TSHR | |
| SCHEMBL15391420 | 0.76 | CYP19A1 (0.57) | MAPTMEN1KMT2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0476659-B1 | A 3(5)-Hydrazinopyrazole compound | FUJI PHOTO FILM CO LTD (JP) | 2001-12-19 | — | — | EP | disclosed |
| US-5235058-A | Photographic couplers | FUJI PHOTO FILM CO., LTD. (JP) | 1993-08-10 | — | — | US | disclosed |
| EP-0476659-A1 | A 3(5)-Hydrazinopyrazole compound | Fuji Photo Film Co., Ltd. (JP) | 1992-03-25 | — | — | EP | disclosed |