Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.43 |
| ▸ | PDE4A | P27815 | 8/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3792986 | 0.81 | SLC9A1 (0.47) | ADRA1DADRA1AADRA1BPDE4APDE4B | |
| SCHEMBL14639338 | 0.78 | ADORA2A (0.42) | ADRA1DADRA1AADRA1BPDE4APDE4B | |
| SCHEMBL5578130 | 0.76 | ALDH1A1 (0.30) | — | |
| SCHEMBL7822379 | 0.74 | ADRA1A (0.50) | ADRA1DADRA1AADRA1BPDE4APDE4B | |
| SCHEMBL7274821 | 0.72 | ADORA2A (0.43) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL13469216 | 0.72 | ADORA2A (0.35) | ADRA1DADRA1AADRA1BPDE4APDE4B | |
| SCHEMBL7213477 | 0.71 | ADRA1D (0.36) | ADRA1DADRA1AADRA1BPDE4APDE4B | |
| SCHEMBL26948740 | 0.71 | ADORA2B (0.44) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL15110502 | 0.69 | SLC9A1 (0.51) | ADRA1DADRA1AADRA1BPDE4APDE4B | |
| SCHEMBL16581427 | 0.69 | ADORA2A (0.48) | ADRA1DADRA1AADRA1BPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748800-B1 | Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-5859014-A | USEFUL IN TREATMENT OF DISEASES INVOLVING DIRECTLY OR INDIRECTLY AN OBSTRUCTION OF THE LOWER URINARY TRACT, SUCH ASBENIGN PROSTATE HYPERPLASIA | SYNTEX (U.S.A.) INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0748800-A2 | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-18 | — | — | EP | disclosed |