Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 4/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8580006 | 0.86 | ALDH1A1 (0.46) | GRM5ADRA1DADRA1AADRA1BNPC1 | |
| SCHEMBL7833743 | 0.81 | ADRA1A (0.57) | ADRA1DADRA1AADRA1BHTR1ASLC6A2 | |
| SCHEMBL5240191 | 0.81 | L3MBTL1 (0.49) | ADRA1DADRA1AADRA1BHTR1AL3MBTL1 | |
| SCHEMBL18036632 | 0.80 | ALDH1A1 (0.49) | ADRA1DADRA1AADRA1BALDH1A1LMNA | |
| SCHEMBL7961982 | 0.80 | L3MBTL1 (0.51) | ADRA1DADRA1AADRA1BNPC1ALDH1A1 | |
| SCHEMBL5339319 | 0.74 | HTR1A (0.55) | ALDH1A1HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24712880 | 0.73 | DRD2 (0.59) | ADRA1DADRA1AADRA1BALDH1A1CYP3A4 | |
| SCHEMBL5234580 | 0.72 | GAA (0.46) | ADRA1DADRA1AADRA1BNPC1ALDH1A1 | |
| SCHEMBL18036657 | 0.70 | L3MBTL1 (0.46) | ALDH1A1LMNANPSR1L3MBTL1 | |
| SCHEMBL7341055 | 0.70 | TSHR (0.60) | RAB9AALDH1A1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748800-B1 | Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-5859014-A | USEFUL IN TREATMENT OF DISEASES INVOLVING DIRECTLY OR INDIRECTLY AN OBSTRUCTION OF THE LOWER URINARY TRACT, SUCH ASBENIGN PROSTATE HYPERPLASIA | SYNTEX (U.S.A.) INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0748800-A2 | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-18 | — | — | EP | disclosed |