Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGG1 | O15527 | 1/20 | 0.46 |
| ▸ | WDR5 | P61964 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846468 | 0.81 | MAPT (0.38) | CTSLGAAALDH1A1MAPTIDO1 | |
| SCHEMBL7841594 | 0.77 | ALDH1A1 (0.39) | GAAALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL9627765 | 0.76 | OGG1 (0.51) | OGG1WDR5ALDH1A1MAPTKDM4E | |
| SCHEMBL28441708 | 0.76 | OGG1 (0.48) | OGG1GAAALDH1A1KDM4EKMT2A | |
| SCHEMBL8495864 | 0.75 | OGG1 (0.50) | OGG1WDR5GAAALDH1A1KDM4E | |
| SCHEMBL7659746 | 0.72 | WDR5 (0.51) | OGG1WDR5GAAALDH1A1MAPT | |
| SCHEMBL217700 | 0.71 | WDR5 (0.46) | OGG1WDR5KDM4EHTTKMT2A | |
| SCHEMBL8059971 | 0.70 | KMT2A (0.49) | OGG1WDR5KDM4EHTTKMT2A | |
| SCHEMBL7162074 | 0.69 | WDR5 (0.44) | OGG1WDR5GAAHTTKMT2A | |
| SCHEMBL8371469 | 0.68 | PGR (0.44) | OGG1WDR5KDM4EHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |