Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7408533 | 0.81 | KMT2A (0.45) | LMNASMN1; SMN2ALDH1A1MAPTKDM4E | |
| SCHEMBL28467697 | 0.78 | MEN1 (0.46) | LMNASMN1; SMN2ALDH1A1MAPTKDM4E | |
| SCHEMBL11488531 | 0.73 | ALDH1A1 (0.46) | LMNASMN1; SMN2ALDH1A1MAPTKDM4E | |
| SCHEMBL220091 | 0.69 | LMNA (0.48) | LMNASMN1; SMN2ALDH1A1MAPTKMT2A | |
| SCHEMBL6482139 | 0.68 | L3MBTL1 (0.41) | LMNASMN1; SMN2ALDH1A1MAPTKMT2A | |
| SCHEMBL7841594 | 0.68 | ALDH1A1 (0.39) | LMNASMN1; SMN2ALDH1A1MAPTKDM4E | |
| SCHEMBL16220948 | 0.68 | RAB9A (0.53) | LMNASMN1; SMN2ALDH1A1MAPTKDM4E | |
| SCHEMBL27638035 | 0.67 | LMNA (0.46) | LMNASMN1; SMN2ALDH1A1MAPTKDM4E | |
| SCHEMBL7842555 | 0.67 | OGG1 (0.46) | ALDH1A1MAPTKDM4EKMT2ASLC6A4 | |
| SCHEMBL21807619 | 0.67 | LMNA (0.41) | LMNASMN1; SMN2ALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |