Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUSP5 | Q16690 | 4/20 | 0.40 |
| ▸ | DUSP6 | Q16828 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.36 |
| ▸ | PKLR | P30613 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7909485 | 0.78 | ING2 (0.39) | PKLRLMNATDP1PKMNPC1 | |
| SCHEMBL11643499 | 0.78 | ING2 (0.39) | PKLRLMNATDP1PKMNPC1 | |
| SCHEMBL30298635 | 0.72 | ING2 (0.37) | PKLRTDP1PKMRAB9ATSHR | |
| SCHEMBL7784537 | 0.72 | ING2 (0.37) | TDP1TSHR | |
| SCHEMBL28706397 | 0.69 | MAPT (0.33) | LMNATDP1L3MBTL1 | |
| SCHEMBL29213549 | 0.69 | PTPN1 (0.47) | DUSP5DUSP6PTPN1PKLRLMNA | |
| SCHEMBL124132 | 0.68 | DUSP5 (0.54) | DUSP5DUSP6PTPN1PKLRLMNA | |
| SCHEMBL14067104 | 0.68 | ITGB2 (0.38) | LMNANPC1 | |
| SCHEMBL102784 | 0.68 | ITGB2 (0.38) | LMNANPC1 | |
| SCHEMBL29958439 | 0.67 | ITGB2 (0.41) | LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200511-B1 | OUTER LAYER OF A COPOLYMER OR OF A MIXTURE OF POLYMERS WHICH COMPRISES AT LEAST 35 MOL % OF ETHYLENE 2,6-NAPHTHALATE UNITS, UP TO 44 MOL % OF ETHYLENE TEREPHTHALATE UNITS, AND FROM 1 TO 20 MOL % OF ETHYLENE ISOPHTHALATE UNITS | MITSUBISHI POLYESTER FILM GMBH (DE) | 2001-03-13 | — | — | US | disclosed |