SCHEMBL7920588

SCHEMBL7920588

N#Cc1c(C(F)(F)F)ccc(F)c1N

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 2/20 0.42
ALDH1A1 P00352 7/20 0.36
GAA P10253 7/20 0.36
KDM4E B2RXH2 6/20 0.36
HTT P42858 5/20 0.36
KMT2A Q03164 2/20 0.36
MAPT P10636 2/20 0.36
CUL4A Q13619 1/20 0.35
GLA P06280 6/20 0.35
HPGD P15428 6/20 0.35
LMNA P02545 3/20 0.35
POLB P06746 1/20 0.35
NCOA1 Q15788 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
HIF1A Q16665 1/20 0.35
NCOA3 Q9Y6Q9 1/20 0.35
MEN1 O00255 1/20 0.35
CRHBP P24387 1/20 0.35
CRHR2 Q13324 1/20 0.35
TP53 P04637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27319871 0.81 AR (0.42) ARPGR
SCHEMBL6706548 0.80 KIF11 (0.44) KIF11ALDH1A1GAAKDM4EHTT
SCHEMBL1462237 0.79 TRPV4 (0.39) ALDH1A1GAAKDM4EMAPTCUL4A
SCHEMBL25983203 0.79 KIF11 (0.44) KIF11ALDH1A1GAAKDM4EHTT
SCHEMBL7920528 0.77 KIF11 (0.42) KIF11ALDH1A1GAAKDM4EHTT
SCHEMBL27414564 0.75 ALDH1A1 (0.46) ALDH1A1GAAKDM4EHTTKMT2A
SCHEMBL15846053 0.75 KDM4E (0.47) ALDH1A1GAAKDM4EKMT2AMAPT
SCHEMBL2431864 0.73 KIF11 (0.39) KIF11ALDH1A1GAAKDM4EHTT
SCHEMBL9219920 0.73 KIF11 (0.44) KIF11GAAGLAPOLBAR
SCHEMBL646513 0.72 L3MBTL1 (0.44) KIF11ALDH1A1GAAKDM4EHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0847977-B1 2,3-DIHALOGENO-6-TRIFLUOROMETHYLBENZENE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME NIPPON SODA CO (JP) 2001-08-29 EP claimed
EP-0847977-B1 2,3-DIHALOGENO-6-TRIFLUOROMETHYLBENZENE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME NIPPON SODA CO (JP) 2001-08-29 EP disclosed
US-6054624-A USEFUL AS THE STARTING MATERIALS FOR PRODUCING PESTICIDES, DRUGS AND THE LIKE NIPPON SODA CO., LTD. (JP) 2000-04-25 US disclosed
US-6054605-A CHEMICAL INTERMEDIATE FOR DRUGS, PESTICIDES NIPPON SODA CO., LTD. (JP) 2000-04-25 US disclosed
EP-0847977-A1 2,3-DIHALOGENO-6-TRIFLUOROMETHYLBENZENE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME NIPPON SODA CO., LTD. (JP) 1998-06-17 EP disclosed