Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOST | Q9BQB4 | 1/20 | 0.69 |
| ▸ | FPGS | Q05932 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GART | P22102 | 3/20 | 0.51 |
| ▸ | NOS1 | P29475 | 6/20 | 0.48 |
| ▸ | NOS3 | P29474 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | MTHFD1 | P11586 | 1/20 | 0.44 |
| ▸ | ATIC | P31939 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9485867 | 0.95 | SOST (0.74) | SOSTFPGSLMNAGARTNOS1 | |
| Water SCHEMBL9486835 | 0.95 | SOST (0.73) | SOSTFPGSLMNAGARTNOS1 | |
| SCHEMBL50298 | 0.89 | SOST (0.78) | SOSTFPGSLMNAGARTNOS1 | |
| SCHEMBL716106 | 0.89 | SOST (0.78) | SOSTFPGSLMNAGARTNOS1 | |
| SCHEMBL15121249 | 0.89 | SOST (0.78) | SOSTFPGSLMNAGARTNOS1 | |
| SCHEMBL3953439 | 0.89 | SOST (0.78) | SOSTFPGSLMNAGARTNOS1 | |
| SCHEMBL27708884 | 0.88 | SOST (0.77) | SOSTFPGSLMNAGARTNOS1 | |
| SCHEMBL28469783 | 0.88 | SOST (0.77) | SOSTFPGSLMNAGARTNOS1 | |
| Tetrahydrofolate SCHEMBL1890563 | 0.88 | SOST (0.77) | SOSTFPGSLMNAGARTNOS1 | |
| Tetrahydrofolate SCHEMBL19376768 | 0.88 | SOST (0.77) | SOSTFPGSLMNAGARTNOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0482493-B1 | Pharmaceutical compositions active in the therapy of neurological affections in aids patients, containing as an active principle at least S-adenosyl-L-methionine salt. | KNOLL FARMACEUTICI S P A (IT) | 2001-02-28 | — | — | EP | disclosed |