Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 2/20 | 0.30 |
| ▸ | HTR7 | P34969 | 2/20 | 0.30 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.30 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.30 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7939132 | 0.89 | HTR1A (0.30) | HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL4482811 | 0.86 | HTR1A (0.32) | HTR1AHTR7NISCHCA12CA1 | |
| Hydrochloric Acid SCHEMBL7935405 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL4463611 | 0.82 | SLC6A2 (0.33) | — | |
| SCHEMBL4094237 | 0.79 | HTR7 (0.36) | HTR1AHTR7ENPP3ENPP1NISCH | |
| Hydrochloric Acid SCHEMBL7644444 | 0.79 | SLC6A2 (0.33) | — | |
| SCHEMBL8202026 | 0.77 | HTR7 (0.34) | HTR1AHTR7CA12CA1CA2 | |
| SCHEMBL8204448 | 0.77 | DHFR (0.34) | HTR1AHTR7ENPP3ENPP1NISCH | |
| Hydrochloric Acid SCHEMBL7935667 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL4060835 | 0.73 | ALDH1A1 (0.35) | HTR1AHTR7ENPP3ENPP1NISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184402-B1 | RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES | CHISSO CORPORATION (JP) | 2001-02-06 | — | — | US | disclosed |