SCHEMBL7935563

SCHEMBL7935563

NC(=O)NCCC(F)(F)F

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CFTR P13569 1/20 0.37
ALDH1A1 P00352 2/20 0.36
POLB P06746 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
TSHR P16473 4/20 0.35
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
HDAC3 O15379 1/20 0.32
MTNR1A P48039 1/20 0.32
CA5A P35218 3/20 0.31
CA3 P07451 2/20 0.31
CA5B Q9Y2D0 2/20 0.31
CA2 P00918 2/20 0.31
CA9 Q16790 2/20 0.31
CA12 O43570 1/20 0.31
CA4 P22748 1/20 0.31
CA6 P23280 1/20 0.31
CA7 P43166 1/20 0.31
CA14 Q9ULX7 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29700581 0.86 ALDH1A1 (0.43) ALDH1A1POLBSMN1; SMN2TSHRMEN1
SCHEMBL15270731 0.81 MLYCD (0.36) ALDH1A1POLBSMN1; SMN2TSHRMEN1
SCHEMBL4057292 0.79 CFTR (0.35) CFTRALDH1A1POLBSMN1; SMN2MEN1
SCHEMBL7938534 0.79 SMN1; SMN2 (0.39) CFTRALDH1A1POLBSMN1; SMN2MEN1
SCHEMBL15270026 0.78 MLYCD (0.34) ALDH1A1POLBSMN1; SMN2TSHRMEN1
SCHEMBL6721810 0.77 ALDH1A1 (0.37) CFTRALDH1A1POLBSMN1; SMN2MEN1
SCHEMBL3907144 0.77 CFTR (0.38) CFTRALDH1A1POLBSMN1; SMN2MEN1
SCHEMBL20045680 0.76 CA2 (0.36) CFTRALDH1A1POLBSMN1; SMN2MEN1
SCHEMBL15923866 0.76 CFTR (0.36) CFTRALDH1A1POLBSMN1; SMN2MEN1
SCHEMBL15621085 0.76 ALDH1A1 (0.35) CFTRALDH1A1POLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4493546-B1 IMIDAZOLE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS ACESION PHARMA APS (DK) 2026-05-06 EP claimed
US-20260028333-A1 NEW COMPOUNDS VICORE PHARMA AB (SE) 2026-01-29 US claimed
EP-4493546-A1 IMIDAZOLE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS ACESION PHARMA APS (DK) 2025-01-22 EP claimed
US-12030856-B2 Potassium channel inhibitors ACESION PHARMA APS (DK) 2024-07-09 US claimed
US-20230399301-A1 NOVEL POTASSIUM CHANNEL INHIBITORS ACESION PHARMA APS (DK) 2023-12-14 US claimed
WO-2023174836-A1 IMIDAZOLE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS ACESION PHARMA APS (DK) 2023-09-21 WO claimed
EP-4245753-A1 IMIDAZOLE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS Acesion Pharma ApS (DK) 2023-09-20 EP claimed
US-20220388994-A1 NEW COMPOUNDS VICORE PHARMA AB (SE) 2022-12-08 US claimed
EP-4031240-A1 NEW COMPOUNDS Vicore Pharma AB (SE) 2022-07-27 EP claimed
CN-114786774-A Novel compounds 维科尔药物公司 2022-07-22 CN claimed
EP-4493546-B1 IMIDAZOLE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS ACESION PHARMA APS (DK) 2026-05-06 EP disclosed
US-20260028333-A1 NEW COMPOUNDS VICORE PHARMA AB (SE) 2026-01-29 US disclosed
EP-4493546-A1 IMIDAZOLE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS ACESION PHARMA APS (DK) 2025-01-22 EP disclosed
US-12152018-B2 Compounds and compositions for treating conditions associated with STING activity IFM DUE, INC. (US) 2024-11-26 US disclosed
US-12030856-B2 Potassium channel inhibitors ACESION PHARMA APS (DK) 2024-07-09 US disclosed
WO-2013134298-A1 RAF INHIBITOR COMPOUNDS DECIPHERA PHARMACEUTICALS, LLC (US) 2013-09-12 WO disclosed
WO-2013041652-A1 MORPHOLINO SUBSTITUTED UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS CELLZOME LIMITED (GB) 2013-03-28 WO disclosed
EP-2346820-B1 OXYCARBAMOYL COMPOUNDS AND THE USE THEREOF SHIONOGI & CO (JP) 2013-02-13 EP disclosed
US-6218498-B1 USEFUL IN PREPARING MOISTURE CURABLE RTV-1 COMPOSITIONS, AND ARE USEFUL IN DIVERSE PROCESSES WHERE SCAVENGING OF PROTIC MATERIALS, PARTICULARLY WATER, IS DESIRED. WACKER-CHEMIE GMBH (DE) 2001-04-17 US disclosed
CN-1242016-A Organosilicon compounds having urea groups, method for producting same and their utilization WACKER CHEMIE GMBH (DE) 2000-01-19 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260028333-A1 NEW COMPOUNDS AGTR1, AGTR2, REN CFTR 10/4885ALDH1A1 2909/4885POLB 3666/4885
US-20220388994-A1 NEW COMPOUNDS RXFP3, RXFP4, RXFP1 CFTR 121/4885ALDH1A1 2970/4885POLB 4323/4885
US-12030856-B2 Potassium channel inhibitors KCNJ2, KCNN2, KCNN1 CFTR 121/4885ALDH1A1 1620/4885POLB 4558/4885
US-12152018-B2 Compounds and compositions for treating conditions associated with STING activity STING1, CGAS, IRF3 CFTR 12/4885ALDH1A1 4418/4885POLB 280/4885
US-20230399301-A1 NOVEL POTASSIUM CHANNEL INHIBITORS KCNN2, KCNJ2, KCNN1 CFTR 139/4885ALDH1A1 1874/4885POLB 4606/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.