Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | MMP1 | P03956 | 3/20 | 0.33 |
| ▸ | MMP9 | P14780 | 3/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947136 | 0.75 | ADAM17 (0.44) | P2RX7ADAM17LMNAGAAMMP1 | |
| SCHEMBL7957560 | 0.71 | GHSR (0.37) | ADAM17LMNATDP1TSHRMAPK1 | |
| SCHEMBL6940930 | 0.70 | ADAM17 (0.40) | ADAM17LMNAGAAMMP1MMP9 | |
| SCHEMBL6988956 | 0.68 | HTR2A (0.36) | LMNAMMP1MMP9PPARGCTSS | |
| SCHEMBL6945362 | 0.66 | ADAM17 (0.54) | ADAM17LMNAMMP1MMP9MAPK1 | |
| SCHEMBL6942351 | 0.65 | HTR2A (0.36) | ADAM17 | |
| SCHEMBL6942735 | 0.64 | ADAM17 (0.42) | ADAM17GAAMMP1MMP9MMP2 | |
| SCHEMBL6942710 | 0.63 | ADAM17 (0.46) | ADAM17LMNAGAAMMP1MMP9 | |
| SCHEMBL7935009 | 0.63 | ADAM17 (0.76) | ADAM17MMP1MMP9MMP13PSMB5 | |
| SCHEMBL6220557 | 0.63 | ADAM17 (0.45) | ADAM17MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |