Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969073 | 0.93 | MTNR1B (0.35) | POLBALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL7948263 | 0.93 | HPGD (0.36) | POLBMMP1MMP2MMP3MMP8 | |
| SCHEMBL7947285 | 0.93 | HPGD (0.36) | POLBMMP1MMP2MMP3MMP8 | |
| SCHEMBL7938408 | 0.85 | CYP2C9 (0.43) | POLBGAAMMP2MMP8MMP13 | |
| SCHEMBL7993224 | 0.85 | MEN1 (0.42) | POLBHTTCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL7947164 | 0.84 | PLA2G2A (0.37) | POLBL3MBTL1ALDH1A1KMT2AMEN1 | |
| SCHEMBL7938360 | 0.84 | POLB (0.36) | POLBL3MBTL1ALDH1A1KMT2AMEN1 | |
| SCHEMBL7945107 | 0.83 | POLB (0.36) | POLBL3MBTL1ALDH1A1 | |
| SCHEMBL7948016 | 0.83 | POLB (0.38) | POLBMMP3L3MBTL1HTTCYP3A4 | |
| SCHEMBL7946077 | 0.82 | POLB (0.35) | POLBMMP1MMP2MMP3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |