Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947285 | 1.00 | HPGD (0.36) | HPGDSMN1; SMN2MTNR1BKMT2AALDH1A1 | |
| SCHEMBL7969073 | 0.98 | MTNR1B (0.35) | HPGDSMN1; SMN2MTNR1BKMT2AALDH1A1 | |
| SCHEMBL7938405 | 0.93 | FKBP1A (0.38) | KMT2AALDH1A1POLBMEN1L3MBTL1 | |
| SCHEMBL7947164 | 0.87 | PLA2G2A (0.37) | KMT2AALDH1A1POLBMEN1L3MBTL1 | |
| SCHEMBL7938360 | 0.86 | POLB (0.36) | KMT2AALDH1A1POLBMEN1L3MBTL1 | |
| SCHEMBL7982224 | 0.86 | RAB9A (0.34) | KMT2AALDH1A1MEN1 | |
| SCHEMBL7948016 | 0.86 | POLB (0.38) | SMN1; SMN2KMT2AALDH1A1POLBMEN1 | |
| SCHEMBL7945107 | 0.86 | POLB (0.36) | ALDH1A1POLBL3MBTL1PTGDR2 | |
| SCHEMBL7946077 | 0.85 | POLB (0.35) | KMT2AALDH1A1POLBMEN1L3MBTL1 | |
| SCHEMBL7937873 | 0.84 | HTR2A (0.41) | KMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |