Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7945107 | 0.92 | POLB (0.36) | POLBALDH1A1MAPTL3MBTL1SLC2A1 | |
| SCHEMBL7946077 | 0.91 | POLB (0.35) | POLBALDH1A1MAPTL3MBTL1SLC2A1 | |
| SCHEMBL7947164 | 0.90 | PLA2G2A (0.37) | POLBALDH1A1MAPTL3MBTL1SLC2A1 | |
| SCHEMBL7986761 | 0.90 | HTT (0.36) | POLBALDH1A1MAPTL3MBTL1MEN1 | |
| SCHEMBL7948016 | 0.88 | POLB (0.38) | POLBALDH1A1MAPTL3MBTL1SLC6A9 | |
| SCHEMBL7982833 | 0.87 | PKM (0.33) | NPC1RAB9AKMT2A | |
| SCHEMBL7992668 | 0.87 | SIGMAR1 (0.45) | RAB9A | |
| SCHEMBL7947285 | 0.86 | HPGD (0.36) | POLBALDH1A1L3MBTL1PTGDR2MEN1 | |
| SCHEMBL7969073 | 0.86 | MTNR1B (0.35) | POLBALDH1A1PTGDR2MEN1KMT2A | |
| SCHEMBL7946743 | 0.86 | MITF (0.45) | POLBALDH1A1MAPTL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |