Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7993224 | 0.84 | MEN1 (0.42) | NPC1RAB9AKMT2AMEN1CYP1A2 | |
| SCHEMBL7985982 | 0.79 | KMT2A (0.40) | NPC1RAB9AKMT2AMEN1CYP1A2 | |
| SCHEMBL7951886 | 0.78 | MITF (0.45) | NPC1RAB9AKMT2AMEN1CYP1A2 | |
| SCHEMBL7946743 | 0.78 | MITF (0.45) | NPC1RAB9AKMT2AMEN1CYP1A2 | |
| SCHEMBL7947062 | 0.78 | MITF (0.43) | NPC1RAB9AKMT2AMEN1CYP1A2 | |
| SCHEMBL7948614 | 0.78 | POLB (0.40) | NPC1RAB9APOLBEPHX2ALDH1A1 | |
| SCHEMBL7938405 | 0.75 | FKBP1A (0.38) | KMT2AMEN1CYP3A4CYP2C19POLB | |
| SCHEMBL7998793 | 0.75 | MITF (0.41) | NPC1RAB9AKMT2AMEN1CYP1A2 | |
| SCHEMBL7948016 | 0.74 | POLB (0.38) | NPC1RAB9AKMT2AMEN1CYP1A2 | |
| SCHEMBL7947164 | 0.74 | PLA2G2A (0.37) | NPC1RAB9AKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |