Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7938360 | 0.86 | POLB (0.36) | POLBALDH1A1MAPTL3MBTL1EPHX2 | |
| SCHEMBL7947164 | 0.85 | PLA2G2A (0.37) | POLBALDH1A1MAPTL3MBTL1EPHX2 | |
| SCHEMBL7951889 | 0.84 | KMT2A (0.41) | POLBALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL7986761 | 0.84 | HTT (0.36) | POLBALDH1A1KDM4EUSP2HPGD | |
| SCHEMBL7945107 | 0.84 | POLB (0.36) | POLBALDH1A1MAPTL3MBTL1EPHX2 | |
| SCHEMBL7948016 | 0.84 | POLB (0.38) | POLBALDH1A1KDM4EMAPTL3MBTL1 | |
| SCHEMBL7946077 | 0.83 | POLB (0.35) | POLBALDH1A1MAPTL3MBTL1EPHX2 | |
| SCHEMBL7969135 | 0.82 | BCHE (0.38) | NPC1RAB9A | |
| SCHEMBL7947094 | 0.82 | POLB (0.37) | POLBALDH1A1KDM4EMAPTEPHX2 | |
| SCHEMBL7969073 | 0.82 | MTNR1B (0.35) | POLBALDH1A1KDM4EHPGDPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |