Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7993224 | 0.87 | MEN1 (0.42) | KMT2AMEN1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7947322 | 0.84 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1KDM4ENPSR1USP2 | |
| SCHEMBL7979068 | 0.81 | PDE2A (0.40) | SMN1; SMN2ALDH1A1KDM4ENPSR1USP2 | |
| SCHEMBL7946743 | 0.80 | MITF (0.45) | KMT2AMEN1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7947062 | 0.80 | MITF (0.43) | KMT2AMEN1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7951886 | 0.80 | MITF (0.45) | KMT2AMEN1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7938411 | 0.79 | NPC1 (0.36) | KMT2AMEN1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7998793 | 0.77 | MITF (0.41) | KMT2AMEN1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7951889 | 0.77 | KMT2A (0.41) | KMT2AMEN1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7946774 | 0.77 | SLC6A9 (0.35) | KMT2AMEN1ALDH1A1KDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |