Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 11/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | PDE6D | O43924 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 9/20 | 0.37 |
| ▸ | HTR7 | P34969 | 9/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947592 | 0.88 | RAB9A (0.36) | HTR2AHTR1APDE6DRAB9ACYP2D6 | |
| SCHEMBL7944087 | 0.86 | BCHE (0.37) | PDE6DCYP2D6BCHE | |
| SCHEMBL7937873 | 0.85 | HTR2A (0.41) | HTR2AHTR2CHTR7DRD2 | |
| SCHEMBL7938073 | 0.84 | HRH3 (0.37) | TP53CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL7945088 | 0.83 | HDAC1 (0.38) | RAB9ACYP2D6BCHE | |
| SCHEMBL7946321 | 0.81 | TERT (0.37) | BCHE | |
| SCHEMBL7986076 | 0.81 | HDAC1 (0.36) | CYP2D6BCHE | |
| SCHEMBL7969135 | 0.77 | BCHE (0.38) | RAB9ACYP2D6BCHE | |
| SCHEMBL7949581 | 0.77 | CXCR4 (0.38) | DRD2BCHE | |
| SCHEMBL7944573 | 0.76 | TDP1 (0.37) | TP53CYP1A2CYP2D6TDP1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |