Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.41 |
| ▸ | HTR2C | P28335 | 5/20 | 0.41 |
| ▸ | HTR7 | P34969 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7992668 | 0.88 | SIGMAR1 (0.45) | HTR2AHTR2CHTR7HRH3 | |
| SCHEMBL7969063 | 0.86 | CYP2D6 (0.42) | KDM4EALDH1A1KMT2APOLBMAPT | |
| SCHEMBL7945535 | 0.86 | KDM4E (0.41) | HTR2AKDM4EALDH1A1KMT2AHRH3 | |
| SCHEMBL7945174 | 0.85 | HTR2A (0.40) | HTR2AHTR2CHTR7DRD2 | |
| SCHEMBL7947285 | 0.84 | HPGD (0.36) | ALDH1A1KMT2APOLB | |
| SCHEMBL7948263 | 0.84 | HPGD (0.36) | ALDH1A1KMT2APOLB | |
| SCHEMBL7969073 | 0.83 | MTNR1B (0.35) | KDM4EALDH1A1KMT2APOLB | |
| SCHEMBL7947164 | 0.82 | PLA2G2A (0.37) | ALDH1A1KMT2APOLBMAPT | |
| SCHEMBL7938360 | 0.81 | POLB (0.36) | ALDH1A1KMT2APOLBMAPT | |
| SCHEMBL7948614 | 0.81 | POLB (0.40) | KDM4EALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |