Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | ALPI | P09923 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.32 |
| ▸ | TMIGD3 | P0DMS9 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | EEF2K | O00418 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7937861 | 0.93 | TLR9 (0.35) | TLR9ADORA2BADORA2AADORA1TMIGD3 | |
| SCHEMBL7944093 | 0.84 | STIM1 (0.38) | TLR9ADORA2BADORA2AADORA1TMIGD3 | |
| SCHEMBL7946084 | 0.76 | HRH4 (0.37) | TLR9ADORA2BADORA2AADORA1KDM4E | |
| SCHEMBL7937747 | 0.75 | HSF1 (0.35) | ADORA2AADORA1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL7943760 | 0.70 | CD38 (0.37) | ADORA2BADORA2AADORA1TMIGD3KDM4E | |
| SCHEMBL7943995 | 0.68 | HSF1 (0.36) | ADORA2AADORA1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL7944574 | 0.64 | HSF1 (0.36) | ADORA2BADORA2AADORA1HPGD | |
| SCHEMBL7937752 | 0.64 | ADORA2A (0.39) | ADORA2BADORA2AADORA1ALDH1A1HPGD | |
| SCHEMBL3227728 | 0.64 | SCN8A (0.37) | ALDH1A1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL20145277 | 0.57 | TLR8 (0.47) | ALDH1A1CYP1A2LMNATP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010008775-A1 | AMINOPYRIDOPYRAZINONE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | disclosed |