Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947322 | 0.84 | ALDH1A1 (0.40) | ALDH1A1MAPTL3MBTL1POLBKDM4E | |
| SCHEMBL7948614 | 0.84 | POLB (0.40) | NPC1RAB9AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL7946271 | 0.81 | ATM (0.43) | KMT2ANPC1RAB9AALDH1A1POLB | |
| SCHEMBL7979068 | 0.81 | PDE2A (0.40) | ALDH1A1MAPTL3MBTL1KDM4EHPGD | |
| SCHEMBL7938360 | 0.79 | POLB (0.36) | KMT2ANPC1RAB9AALDH1A1MAPT | |
| SCHEMBL7945535 | 0.79 | KDM4E (0.41) | KMT2AALDH1A1MAPTPOLBKDM4E | |
| SCHEMBL7947164 | 0.78 | PLA2G2A (0.37) | KMT2ANPC1RAB9AALDH1A1MAPT | |
| SCHEMBL7946579 | 0.77 | HDAC8 (0.38) | ALDH1A1KDM4E | |
| SCHEMBL7985982 | 0.77 | KMT2A (0.40) | KMT2ANPC1RAB9AALDH1A1MAPT | |
| SCHEMBL7948016 | 0.76 | POLB (0.38) | KMT2ANPC1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |